Basic information Safety Supplier Related

HS-PEG5-CH2CH2COOH

Basic information Safety Supplier Related

HS-PEG5-CH2CH2COOH Basic information

Product Name:
HS-PEG5-CH2CH2COOH
Synonyms:
  • HS-PEG5-CH2CH2COOH
  • 3-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
  • Propanoic acid, 3-[(14-mercapto-3,6,9,12-tetraoxatetradec-1-yl)oxy]-
CAS:
1449390-67-3
MF:
C13H26O7S
MW:
326.41
Mol File:
1449390-67-3.mol
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HS-PEG5-CH2CH2COOH Chemical Properties

Boiling point:
461.0±45.0 °C(Predicted)
Density 
1.150±0.06 g/cm3(Predicted)
pka
4.28±0.10(Predicted)
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HS-PEG5-CH2CH2COOH Usage And Synthesis

Biological Activity

Thiol-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HS-PEG5-CH2CH2COOHSupplier

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