HS-PEG5-CH2CH2COOH
HS-PEG5-CH2CH2COOH Basic information
- Product Name:
- HS-PEG5-CH2CH2COOH
- Synonyms:
-
- HS-PEG5-CH2CH2COOH
- 3-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
- Propanoic acid, 3-[(14-mercapto-3,6,9,12-tetraoxatetradec-1-yl)oxy]-
- CAS:
- 1449390-67-3
- MF:
- C13H26O7S
- MW:
- 326.41
- Mol File:
- 1449390-67-3.mol
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HS-PEG5-CH2CH2COOH Chemical Properties
- Boiling point:
- 461.0±45.0 °C(Predicted)
- Density
- 1.150±0.06 g/cm3(Predicted)
- pka
- 4.28±0.10(Predicted)
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HS-PEG5-CH2CH2COOH Usage And Synthesis
Biological Activity
Thiol-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
HS-PEG5-CH2CH2COOHSupplier
Amatek Scientific Co. Ltd.
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- 0512-56316828
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Xi'an Confluore Biological Technology Co., Ltd.
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TargetMol Chemicals Inc.
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- +1-781-999-5354 +1-00000000000
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Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 15801484223;
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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- 0431-80514535 19917294565
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