HS-PEG5-CH2CH2COOH Chemical Properties

Boiling point:

461.0±45.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

pka

4.28±0.10(Predicted)

HS-PEG5-CH2CH2COOH Usage And Synthesis

Biological Activity

Thiol-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HS-PEG5-CH2CH2COOH(1449390-67-3)Related Product Information

• HO-PEG5-CH2COOtBu
• Hydroxy-PEG1-methyl ester
• Hydroxy-PEG2-CH2CO2H
• Hydroxy-PEG4-CH2CO2Me
• HO-PEG6-CH2COOH
• HS-PEG4-CH2CH2COOH
• HO-PEG3-CH2COOH
• Thiol-PEG5-phosphonic acid
• Thiol-PEG5-t-butyl ester
• HS-PEG5-OH
• HS-PEG5-CH2CH2N3