Trimetazidine N-oxide Chemical Properties

Boiling point:

397.1±42.0 °C(Predicted)

Density 

1.196±0.06 g/cm3(Predicted)

pka

13.23±0.20(Predicted)

Trimetazidine N-oxide Usage And Synthesis

Uses

Trimetazidine-N-oxide is the major active metabolite of Trimetazidine. Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM. Trimetazidine is an effective antianginal agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties.

References

[1] Sigmund G, et al. Doping control analysis of trimetazidine and characterization of major metabolites using mass spectrometric approaches. Drug Test Anal. 2014 Nov-Dec;6(11-12):1197-205. DOI:10.1002/dta.1680

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