Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Aromatic ketones >  3-Chloropropiophenone

3-Chloropropiophenone

Basic information Safety Supplier Related

3-Chloropropiophenone Basic information

Product Name:
3-Chloropropiophenone
Synonyms:
  • 3-CHLORO-1-PHENYL-1-PROPANONE
  • 3-CHLORO-1-OXO-1-PHENYLPROPANE
  • B-CHLOROPROPIOPHENONE
  • BETA-CHLOROPROPIOPHENONE
  • 3-Chloropropiophenone98%
  • Chloropropiophenone, 98+%
  • beta-Chloropropiophenone,98+%
  • 3-Chloropropiophenone, tech., 90%
CAS:
936-59-4
MF:
C9H9ClO
MW:
168.62
EINECS:
213-317-6
Product Categories:
  • Building Blocks
  • C9
  • Ketones
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Aromatics, Impurities, Intermediates
  • API
Mol File:
936-59-4.mol
More
Less

3-Chloropropiophenone Chemical Properties

Melting point:
48-50 °C(lit.)
Boiling point:
113-115 °C4 mm Hg(lit.)
Density 
1.1115 (rough estimate)
refractive index 
1.5350 (estimate)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Pale Yellow
Water Solubility 
Insoluble
BRN 
2043580
Stability:
Stable. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference
936-59-4(CAS DataBase Reference)
NIST Chemistry Reference
1-Propanone, 3-chloro-1-phenyl-(936-59-4)
EPA Substance Registry System
1-Propanone, 3-chloro-1-phenyl- (936-59-4)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
37/39-26-24/25
WGK Germany 
3
TSCA 
Yes
HS Code 
29147000

MSDS

More
Less

3-Chloropropiophenone Usage And Synthesis

Description

3-Chloropropiophenone is a chiral compound that is used as an antidepressant drug. It was first synthesized in the 1950s and has been studied extensively for its pharmacological effects. It is a racemic mixture of two enantiomers, one of which is active and the other inactive. The active enantiomer binds to serotonin receptors and inhibits the reuptake of serotonin, which leads to an increase in serotonin levels. The inactive enantiomer does not bind to serotonin receptors and does not inhibit the reuptake of serotonin. 3-Chloropropiophenone has been shown to be effective when administered at an optimum concentration of 5 milligrams per kilogram body weight.

Chemical Properties

faintly yellow to tan crystalline powder

Uses

3-Chloropropiophenone is an Impurity of Fluoxetine (F597100).

Uses

3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone.

Synthesis

Adding 3' -chlorobenzene acetone and levorotatory prolinol into 95% ethanol and stirring; cooling after the reaction liquid is wholly dissolved; adding potassium borohydride into the reaction solution in batches, and preserving heat after adding; heating the reaction solution for reflux reaction, and concentrating the reaction solution under reduced pressure; adding n-hexane into the reaction solution, heating, and adding active carbon for heat preservation and decoloration; filtering the reaction solution, leaching a filter cake by using normal hexane, and collecting filtrate; crystallizing and filtering the filtrate, leaching the filter cake once with n-hexane, and drying in vacuum to obtain 3-Chloropropiophenone.

3-Chloropropiophenone Preparation Products And Raw materials

Preparation Products

3-ChloropropiophenoneSupplier

Jiaxing Xinbelai Biotechnology Co., LTD Gold
Tel
18167156872
Email
guopeng@synbiolab.cn
Nanjing Tianyi Chemical Technology Co., Ltd Gold
Tel
15150528611
Email
779881375@qq.com
Changzhou Luowan Biological Technology Co., Ltd. Gold
Tel
13646143635
Email
617837247@qq.com
Shanghai Better-In Pharmaceutical Technology Co.,Ltd. Gold
Tel
021-38921049 13564871374
Email
sales@better-in.com
Chongqing Xingcan Pharmaceutical Technology Co., Ltd. Gold
Tel
15523000485
Email
xingcanyaoye@sina.com