3-Chloropropiophenone Chemical Properties

Melting point:

48-50 °C(lit.)

Boiling point:

113-115 °C4 mm Hg(lit.)

Density 

1.1115 (rough estimate)

refractive index 

1.5350 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

Off-White to Pale Yellow

Water Solubility 

Insoluble

BRN 

2043580

Stability:

Stable. Incompatible with strong bases, strong oxidizing agents.

CAS DataBase Reference

936-59-4(CAS DataBase Reference)

NIST Chemistry Reference

1-Propanone, 3-chloro-1-phenyl-(936-59-4)

EPA Substance Registry System

1-Propanone, 3-chloro-1-phenyl- (936-59-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29147000

MSDS

• Language:English Provider:3-Chloro-1-phenyl-1-propanone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Chloropropiophenone Usage And Synthesis

Description

3-Chloropropiophenone is a chiral compound that is used as an antidepressant drug. It was first synthesized in the 1950s and has been studied extensively for its pharmacological effects. It is a racemic mixture of two enantiomers, one of which is active and the other inactive. The active enantiomer binds to serotonin receptors and inhibits the reuptake of serotonin, which leads to an increase in serotonin levels. The inactive enantiomer does not bind to serotonin receptors and does not inhibit the reuptake of serotonin. 3-Chloropropiophenone has been shown to be effective when administered at an optimum concentration of 5 milligrams per kilogram body weight.

Chemical Properties

faintly yellow to tan crystalline powder

Uses

3-Chloropropiophenone is an Impurity of Fluoxetine (F597100).

Uses

3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone.

Synthesis

Adding 3' -chlorobenzene acetone and levorotatory prolinol into 95% ethanol and stirring; cooling after the reaction liquid is wholly dissolved; adding potassium borohydride into the reaction solution in batches, and preserving heat after adding; heating the reaction solution for reflux reaction, and concentrating the reaction solution under reduced pressure; adding n-hexane into the reaction solution, heating, and adding active carbon for heat preservation and decoloration; filtering the reaction solution, leaching a filter cake by using normal hexane, and collecting filtrate; crystallizing and filtering the filtrate, leaching the filter cake once with n-hexane, and drying in vacuum to obtain 3-Chloropropiophenone.

3-Chloropropiophenone(936-59-4)Related Product Information

• 4'-Chloropropiophenone
• Pyruvic acid
• Chlorphenamine maleate
• Phenylhydrazine
• Calcium pyruvate
• Acetylacetone
• 3'-Chloropropiophenone
• Citric acid monohydrate
• Epichlorohydrin
• PHENYL VALERATE
• 3,4'-Dichloropropiophenone
• Difluorochloromethane
• Chloroacetic acid
• DIETHYLPROPION
• Propiophenone
• ALPHA-ACETYLPHENYLACETONITRILE
• Phenylacetone
• p-Dichlorobenzene