HO-PEG5-CH2COOtBu Chemical Properties

Boiling point:

444.5±40.0 °C(Predicted)

Density 

1.182±0.06 g/cm3(Predicted)

pka

3.39±0.10(Predicted)

HO-PEG5-CH2COOtBu Usage And Synthesis

Biological Activity

HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

HO-PEG5-CH2COOtBu(52026-48-9)Related Product Information

• HS-PEG5-CH2CH2COOH
• Hydroxy-PEG1-methyl ester
• Hydroxy-PEG2-CH2CO2H
• Hydroxy-PEG4-CH2CO2Me
• HO-PEG6-CH2COOH
• HS-PEG4-CH2CH2COOH
• HO-PEG3-CH2COOH
• COOH-PEG10-COOtBu
• HOOCCH2CH2-PEG16-CH2CH2COOH
• Acid-PEG4-t-butyl ester
• HOOCCH2CH2O-PEG10-CH2CH2COOH
• Hydroxy-PEG5-acid