Alkyne NHS ester (hexynoic acid NHS ester) Chemical Properties

storage temp. 

Storage temp. -20°C

solubility 

good in organic solvents (DMF, DMSO, DCM)

form 

Liquid

color 

Colorless to light yellow

Appearance

yellowish oil or off white crystals

Alkyne NHS ester (hexynoic acid NHS ester) Usage And Synthesis

Description

5-Hexynoic Acid-NHS Ester contains a propargyl group and an NHS ester group. This reagent is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Uses

5-Hexynoic NHS Ester is a nonclaevable linker for antibody-drug-conjugation. 5-Hexynoic NHS Ester is used in the preparation of biomimetic G-quartet compounds for detection, imaging and purification of G-quartet nucleic acids.

IC 50

Non-cleavable Linker

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