LM22B-10
LM22B-10 Basic information
- Product Name:
- LM22B-10
- Synonyms:
-
- LM22B-10
- 2-[[4-[[4-[BIS-(2-HYDROXYETHYL)-AMINO]-PHENYL]-(4-CHLORO-PHENYL)-METHYL]-PHENYL]-(2-HYDROXY-ETHYL)-AMINO]-ETHANOL
- 2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol
- Ethanol, 2,2',2'',2'''-[[(4-chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis-
- inhibit,Trk Receptor,Akt,LM-22B-10,LM22B-10,LM22B 10,Tropomyosin related kinase receptor,ERK,PKB,Inhibitor,Protein kinase B,Extracellular signal regulated kinases
- CAS:
- 342777-54-2
- MF:
- C27H33ClN2O4
- MW:
- 485.01
- Mol File:
- 342777-54-2.mol
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LM22B-10 Chemical Properties
- Boiling point:
- 718.9±60.0 °C(Predicted)
- Density
- 1.287±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
- form
- A crystalline solid
- pka
- 14.00±0.10(Predicted)
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LM22B-10 Usage And Synthesis
Uses
LM22B-10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.
storage
Store at -20°C
LM22B-10Supplier
MedChemexpress LLC
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