LM22B-10 Chemical Properties

Boiling point:

718.9±60.0 °C(Predicted)

Density 

1.287±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml

form 

A crystalline solid

pka

14.00±0.10(Predicted)

color 

Light green to green

LM22B-10 Usage And Synthesis

Uses

LM22B-10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively. Active in vivo and brain penetrant.

Biological Activity

LM22B-10 is a brain penetrant, potent and selective TrkB and TrkC neurotrophin receptors agonist th at improves cell survival and potently accelerated neurite outgrowth. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells.

storage

Store at -20°C