Basic information Safety Supplier Related

ENTEROSTATIN, HUMAN

Basic information Safety Supplier Related

ENTEROSTATIN, HUMAN Basic information

Product Name:
ENTEROSTATIN, HUMAN
Synonyms:
  • procolipase activation peptide
  • Enterostatin , mouse, rat)
  • L-ALA-PRO-GLY-PRO-ARG SALT
  • ENTEROSTATIN, HUMAN
  • ENTEROSTATIN (HUMAN) ACETATE SALT
  • H-ALA-PRO-GLY-PRO-ARG-OH
  • H-ALA-PRO-GLY-PRO-ARG-OH ACETATE SALT
  • H-ALA-PRO-GLY-PRO-ARG-OH ACOH
CAS:
117830-79-2
MF:
C21H36N8O6
MW:
496.56
Product Categories:
  • Peptide
  • EnterostatinPeptides for Cell Biology
  • Other Obesity PeptidesObesity Research
  • Cytokines Growth Factors and Hormones (Obesity)
  • Hormones
  • Obesity Peptides
  • Obesity Research
  • Other Obesity Research Products
  • Various Peptides
Mol File:
117830-79-2.mol
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ENTEROSTATIN, HUMAN Chemical Properties

Density 
1.54±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble to 0.70 mg/ml in sterile water
form 
Lyophilized solid.
pka
3.60±0.21(Predicted)
color 
White to off-white
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Safety Information

WGK Germany 
3

MSDS

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ENTEROSTATIN, HUMAN Usage And Synthesis

Definition

ChEBI: APGPR Enterostatin is a peptide.

Biological Activity

Enterostatin are pentapeptides that reduce fat intake.

in vitro

In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%).

in vivo

Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake.

target

Human Endogenous Metabolite

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ENTEROSTATIN, HUMANSupplier

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