ENTEROSTATIN, HUMAN
ENTEROSTATIN, HUMAN Basic information
- Product Name:
- ENTEROSTATIN, HUMAN
- Synonyms:
-
- procolipase activation peptide
- Enterostatin , mouse, rat)
- L-ALA-PRO-GLY-PRO-ARG SALT
- ENTEROSTATIN, HUMAN
- ENTEROSTATIN (HUMAN) ACETATE SALT
- H-ALA-PRO-GLY-PRO-ARG-OH
- H-ALA-PRO-GLY-PRO-ARG-OH ACETATE SALT
- H-ALA-PRO-GLY-PRO-ARG-OH ACOH
- CAS:
- 117830-79-2
- MF:
- C21H36N8O6
- MW:
- 496.56
- Product Categories:
-
- Peptide
- EnterostatinPeptides for Cell Biology
- Other Obesity PeptidesObesity Research
- Cytokines Growth Factors and Hormones (Obesity)
- Hormones
- Obesity Peptides
- Obesity Research
- Other Obesity Research Products
- Various Peptides
- Mol File:
- 117830-79-2.mol
ENTEROSTATIN, HUMAN Chemical Properties
- Density
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble to 0.70 mg/ml in sterile water
- form
- Lyophilized solid.
- pka
- 3.60±0.21(Predicted)
MSDS
- Language:English Provider:SigmaAldrich
ENTEROSTATIN, HUMAN Usage And Synthesis
Definition
ChEBI: APGPR Enterostatin is a peptide.
Biological Activity
Enterostatin are pentapeptides that reduce fat intake.
in vitro
In the perfused ratpancreas, Enterostatin, at 100 mM, inhibits the insulin response to 9 mM glucose (by 70%), 0.1 mM tolbutamide (by 40%), and 5 mM arginine (by 70%).
in vivo
Chronically, enterostatin reduces fat intake, bodyweight, and body fat. This response may involve multiple metabolic effects of enterostatin, which include a reduction of insulin secretion, an increase in sympathetic drive to brown adipose tissue, and the stimulation of adrenal corticosteroid secretion. Enterostatin enhances memory consolidation after central or oral administration at a dose of 10 nmol/mouse or 300 mg/kg, respectively, in a step-through type passive avoidance test in mice. A dose of 38 nmol of enterostatin gives a significant inhibition of high-fat food intake, while at a higher dose of 76 nmol the inhibiting effect is lost. During the first hour, after injection of enterostatin, there is even a slight increase in food intake.
target
| Human Endogenous Metabolite < span> |
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