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Cysteamine hydrochloride

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Cysteamine hydrochloride Basic information

Product Name:
Cysteamine hydrochloride
Synonyms:
  • mercaptoethylammonium chloride
  • Mercaptamine hydrochloride
  • DECARBOXYCYSTEINE HCL
  • DECARBOXYCYSTEINE HYDROCHLORIDE
  • CYSTEAMINIUM CHLORIDE
  • CYSTEAMINE HCL
  • CYSTEAMINE HYDROCHLORIDE
  • BETA-MERCAPTOETHYLAMINE HYDROCHLORIDE
CAS:
156-57-0
MF:
C2H8ClNS
MW:
113.61
EINECS:
205-858-1
Product Categories:
  • API intermediates
  • Antioxidant
  • Biochemistry
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Pharmaceutical Intermediates
  • Sulfur compounds
  • Starting Raw Materials & Intermediates
  • Anilines, Aromatic Amines and Nitro Compounds
  • proteinmod
  • produce cosmetics,feed additive,biochemical reagent
  • Inhibitors
Mol File:
156-57-0.mol
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Cysteamine hydrochloride Chemical Properties

Melting point:
67-71 °C
Boiling point:
238.5℃[at 101 325 Pa]
Density 
0.75
vapor pressure 
5.333Pa at 25℃
refractive index 
1.6100 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 1 m at 20 °C, clear, colorless
form 
Crystalline Powder or Pellets
color 
White
PH
3.3-5.0 (400g/l, H2O, 20℃)
Water Solubility 
VERY SOLUBLE
λmax
λ: 280 nm Amax: ≤0.3
Sensitive 
Hygroscopic
Merck 
14,2779
BRN 
3590083
Stability:
Stable, but hygroscopic. Incompatible with strong oxidizing agents.
InChIKey
OGMADIBCHLQMIP-UHFFFAOYSA-N
LogP
-2.14 at 25℃
CAS DataBase Reference
156-57-0(CAS DataBase Reference)
EPA Substance Registry System
Cysteamine hydrochloride (156-57-0)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
36/37/39-26-36
RIDADR 
UN 3335
WGK Germany 
3
RTECS 
KJ0200000
1-3-10-13
TSCA 
Yes
HS Code 
29309070
Toxicity
LD50 orally in Rabbit: 642 mg/kg

MSDS

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Cysteamine hydrochloride Usage And Synthesis

Description

Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.

Chemical Properties

White Solid

Uses

Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.

Uses

Cysteamine hydrochloride has been used in the in-situ generation of chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) for the sensing of Cd2+ and S2-.

Uses

An inhibitor of DMBA-induced mammary tumors2-Mercaptoethylamine hydrochloride acts as a precursor in taurine biosynthesis and component of coenzyme A. It is involved in the preparation of active pharmaceutical ingredients like ranitidine and nizatidine. It acts as an antidote for acetaminophen poisoning. Further, it is used in the oral treatment of nephropathic cystinosis, radiation sickness and disorders of cysteine excretion. In addition to this, it serves as an antioxidant and an inhibitor of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors.

General Description

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.

Hazard

Toxic by inhalation and ingestion.

Biochem/physiol Actions

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. Cysteamine is used in a wide range of applications from regulation of gene expression, to depletion of somatostatin, to coating of nanoparticles.

Purification Methods

Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]

Cysteamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Cysteamine hydrochlorideSupplier

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