Cysteamine hydrochloride Chemical Properties

Melting point:

67-71 °C

Boiling point:

238.5℃[at 101 325 Pa]

Density 

0.75

vapor pressure 

5.333Pa at 25℃

refractive index 

1.6100 (estimate)

storage temp. 

2-8°C

solubility 

H₂O: 1 m at 20 °C, clear, colorless

form 

Crystalline Powder or Pellets

color 

White

PH

3.3-5.0 (400g/l, H2O, 20℃)

Water Solubility 

VERY SOLUBLE

Sensitive 

Hygroscopic

λmax

λ: 280 nm Amax: ≤0.3

Merck 

14,2779

BRN 

3590083

Stability:

Stable, but hygroscopic. Incompatible with strong oxidizing agents.

InChIKey

OGMADIBCHLQMIP-UHFFFAOYSA-N

LogP

-2.14 at 25℃

CAS DataBase Reference

156-57-0(CAS DataBase Reference)

EPA Substance Registry System

Cysteamine hydrochloride (156-57-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

36/37/39-26-36

RIDADR 

UN 3335

WGK Germany 

3

RTECS 

KJ0200000

F 

1-3-10-13

TSCA 

Yes

HS Code 

29309070

Toxicity

LD50 orally in Rabbit: 642 mg/kg

MSDS

• Language:English Provider:Cysteamine hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Cysteamine hydrochloride Usage And Synthesis

Description

Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.

Chemical Properties

White Solid

Uses

An inhibitor of DMBA-induced mammary tumors2-Mercaptoethylamine hydrochloride acts as a precursor in taurine biosynthesis and component of coenzyme A. It is involved in the preparation of active pharmaceutical ingredients like ranitidine and nizatidine. It acts as an antidote for acetaminophen poisoning. Further, it is used in the oral treatment of nephropathic cystinosis, radiation sickness and disorders of cysteine excretion. In addition to this, it serves as an antioxidant and an inhibitor of 7,12-Dimethylbenz[a]anthracene (DMBA)-induced tumors.

Uses

Cysteamine hydrochloride has been used in the in-situ generation of chiral cysteamine-capped cadmium sulfide quantum dots (CA-CdS QDs) for the sensing of Cd²⁺ and S^2-.

Uses

Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.

General Description

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.

Hazard

Toxic by inhalation and ingestion.

Biochem/physiol Actions

Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine. Cysteamine is used in a wide range of applications from regulation of gene expression, to depletion of somatostatin, to coating of nanoparticles.

Synthesis

In particular to synthesizing cysteamine hydrochloride in alkali surroundings, which is characterized in that ethanolamine solution and sulfate solution are used as raw material; 2- amino ethyl sulfate is firstly synthesized before made into ring in alkaline solution by 2-amino ethyl sulfate and carbon disulfide, thereby getting Alpha -mercaptothiazoline; alkaline hydrolysis is made upon Alpha -mercaptothiazoline to produce cysteamine hydrochloride.

Purification Methods

Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]

Cysteamine hydrochloride(156-57-0)Related Product Information

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