NH-bis(PEG2-propargyl) Chemical Properties

Boiling point:

351.0±37.0 °C(Predicted)

Density 

1.030±0.06 g/cm3(Predicted)

storage temp. 

2-8°C, protect from light

solubility 

Soluble in Water, DMSO, DCM, DMF

pka

8.36±0.19(Predicted)

form 

Viscous Liquid

color 

Light yellow to yellow

NH-bis(PEG2-propargyl) Usage And Synthesis

Description

NH-bis(PEG2-propargyl) is a multi-branched linker with two terminal propargyl groups and an amino group. The propargyl groups reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to yield a stable triazole linkage. The amino group is reactive with carboxylic acids, activated NHS esters, and carbonyls.

Uses

NH-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

NH-bis(PEG2-propargyl)(2100306-83-8)Related Product Information

• NH-bis(PEG4-OH)
• NH-bis(PEG4-Boc)
• NH-(PEG3-azide)2
• NH-bis(PEG2-Boc)
• NH-(PEG3-Boc)2