Propargyl-PEG9-amine CAS#: 2093153-98-9

Propargyl-PEG9-amine Basic information

Product Name:

Propargyl-PEG9-amine

Synonyms:

Propargyl-PEG9-amine
Propargyl-PEG9-NH2
Propargyl-PEG9-NH2/3,6,9,12,15,18,21,24,27-Nonaoxatriacont-29-yn-1-amine
3,6,9,12,15,18,21,24,27-Nonaoxatriacont-29-yn-1-amine

CAS:

2093153-98-9

MF:

C21H41NO9

MW:

451.55

Mol File:

2093153-98-9.mol

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Propargyl-PEG9-amine Chemical Properties

Boiling point:: 512.3±45.0 °C(Predicted)
Density: 1.075±0.06 g/cm3(Predicted)
pka: 8.74±0.10(Predicted)
form: Liquid
color: Colorless to light yellow

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Propargyl-PEG9-amine Usage And Synthesis

Description

Propargyl-PEG9-amine has a propargyl group and an amine group. The amine group reacts with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) to form amide bonds. The propargyl group reacts with azides to form triazole linkage with the presence of copper as a catalyst.

Uses

Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.

Propargyl-PEG9-amineSupplier

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