E3 Ligase Ligand-Linker Conjugates 21
E3 Ligase Ligand-Linker Conjugates 21 Basic information
- Product Name:
- E3 Ligase Ligand-Linker Conjugates 21
- Synonyms:
-
- E3 Ligand-Linker Conjugate 9
- E3 Ligase Ligand-Linker Conjugates 21
- E3 Ligase Ligand-Linker Conjugates 14 free base
- Thalidomide-O-amido-PEG3-C2-NH2
- Cereblon Ligand-Linker Conjugates 3
- Acetamide, N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
- Thalidomide-O-amido-PEG3-NH2
- N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide
- CAS:
- 1957236-20-2
- MF:
- C23H30N4O9
- MW:
- 506.51
- Product Categories:
-
- peg
- Mol File:
- 1957236-20-2.mol
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E3 Ligase Ligand-Linker Conjugates 21 Chemical Properties
- Boiling point:
- 788.8±60.0 °C(Predicted)
- Density
- 1.358±0.06 g/cm3(Predicted)
- pka
- 10.68±0.40(Predicted)
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E3 Ligase Ligand-Linker Conjugates 21 Usage And Synthesis
Uses
Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
IC 50
Cereblon
References
[1] Methods to induce targeted protein degradation through bifunctional molecules. WO 2017007612 A1
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E3 Ligase Ligand-Linker Conjugates 21(1957236-20-2)Related Product Information
- E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
- E3 ligase Ligand-Linker Conjugates 4
- E3 ligase Ligand-Linker Conjugates 6
- E3 ligase Ligand-Linker Conjugates 7 Free Base
- E3 Ligase Ligand-Linker Conjugates 22
- E3 ligase Ligand-Linker Conjugates 11
- 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)-
- Cereblon Ligand 1
- E3 Ligase Ligand-Linker Conjugates 19
- Thalidomide-O-PEG4-Propargyl
- Thalidomide-linker 10
- Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-
- Thalidomide-O-amido-C4-NH2 hydrochloride
- Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
- Thalidomide-O-amido-C8-NH2 hydrochloride
- Thalidomide-O-PEG4-Boc
- tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate
- Thalidomide-linker 13