1-Acetylimidazole Chemical Properties

Melting point:

99-105 °C (lit.)

Boiling point:

206.4°C (rough estimate)

Density 

1.2111 (rough estimate)

refractive index 

1.4800 (estimate)

storage temp. 

2-8°C

solubility 

water: soluble50mg/mL, clear, colorless

pka

pKa 3.6(H2O,t = 25,I=0.2) (Uncertain)

form 

Adhering Crystals or Crystalline Powder

color 

White to beige or light tan

Water Solubility 

Hydrolyzes in water. Solubility in methanol (almost transparency).

Sensitive 

Moisture Sensitive

BRN 

108425

Stability:

Moisture Sensitive

CAS DataBase Reference

2466-76-4(CAS DataBase Reference)

NIST Chemistry Reference

1H-Imidazole, 1-acetyl-(2466-76-4)

EPA Substance Registry System

1H-Imidazole, 1-acetyl- (2466-76-4)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

RTECS 

NI3400000

F 

10-21

TSCA 

Yes

HS Code 

29332900

MSDS

• Language:English Provider:NAI
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Acetylimidazole Usage And Synthesis

Chemical Properties

white to beige or light tan adhering crystals or

Uses

Acetylating agent for capping unreacted amino groups in peptide synthesis.

Uses

It is a mild acylating agent and its reactivity can be enhanced by quaternization with, e.g. benzyl bromide. 1-Acetylimidazole was used as acetylation reagent for amino groups. It was also employed for acetylation of histones. It is relatively specific reagent for tyrosyl residue acetylatioa dn a reagent used in the synthesis of annulated imidazole derivatives.

Uses

Relatively specific reagent for tyrosyl residue acetylation. Reagent used in the synthesis of annulated imidazole derivatives.

Definition

ChEBI: N-acetylimidazole is a N-acylimidazole.

General Description

Rate of solvolysis of 1-acetylimidazole in acid solutions was evaluated. Reaction of 1-acetylimidazole with orthophosphate and adenosine-5′-phosphate has been reported.

Purification Methods

It is recrystallised from isopropenyl acetate and dried in a vacuum over P2O5. [Riordan & Valee Methods Enzymol 25 500 1972, Beilstein 23/4 V 218.]

1-Acetylimidazole(2466-76-4)Related Product Information

• N-ACETYL-L-TYROSINE ETHYL ESTER
• 1-Methylimidazole
• Acetylacetone
• Acetylferrocene
• N-BENZOYLIMIDAZOLE
• N,9-Diacetylguanine
• Vat Orange 7
• N-Heptafluorobutyrylimidazole
• 1-(PENTAFLUOROPROPIONYL)IMIDAZOLE
• 1-(Trifluoroacetyl)imidazole
• Vat Red 15
• N-TRANS-CINNAMOYLIMIDAZOLE
• tributyl acetocitrate
• N-PENTAFLUOROBENZOYLIMIDAZOLE
• Imidazol-1-yl-acetic acid
• 1-PROPIONYLIMIDAZOLE
• BENZIMIDAZO[2,1-A]BENZ[D,E]ISOQUINOLION-7-ONE
• THIAZOLO(2 3-B)BENZIMIDAZOLE-3(2H)-ONE