Protopine Chemical Properties

Melting point:

203-205?C

Boiling point:

486.8°C (rough estimate)

Density 

1.399 (calc)

refractive index 

1.5800 (estimate)

storage temp. 

Inert atmosphere,2-8°C

Water Solubility 

Insoluble in water

solubility 

DMSO : 12.5 mg/mL (35.37 mM; Need ultrasonic)

pka

7.86±0.20(Predicted)

form 

powder to crystal

color 

White to Light gray to Light yellow

LogP

3.760 (est)

NIST Chemistry Reference

Protopine(130-86-9)

Safety Information

Safety Statements 

24/25

RIDADR 

1544

RTECS 

VS2800000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29391900

Hazardous Substances Data

130-86-9(Hazardous Substances Data)

Toxicity

guinea pig,LD50,intraperitoneal,116mg/kg (116mg/kg),Therapie. Vol. 28, Pg. 767, 1973.

MSDS

• Language:English Provider:4,6,7,14-Tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c-5',6'-g] azecin-13(5H)-one

Protopine Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Protopine is a Ca2+ channel blocker and antiplatelet agent. Immunomodulator

Definition

ChEBI: A dibenzazecine alkaloid isolated from Fumaria vaillantii.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Purification Methods

It crystallises from EtOH/CHCl3. The picrate has m ~240o(dec). [Beilstein 27 H 558, 17 I 568, 17 II 620, 17 III/IV 6881.]

Protopine(130-86-9)Related Product Information

• Methyl acetate
• Pirimiphos-methyl
• Kresoxim-methyl
• Tribenuron methyl
• METSULFURON METHYL
• Methyl salicylate
• Thiophanate-methyl
• Protoporphyrin IX
• Methyl
• Methyl bromide
• PROTOPINE HCL,PROTOPINE HYDROCHLORIDE
• NSC26657
• DESOXYANISOIN
• 3-METHOXYPHENYLACETONE
• CORYCAVINE
• PIPERONYL METHYL KETONE
• 3'-methoxypropiophenone
• [2-(4-METHOXY-PHENYL)-ETHYL]-METHYL-AMINE