5-Chlorovaleryl chloride Chemical Properties

Boiling point:

38-39 °C0.15 mm Hg(lit.)

Density 

1.206 g/mL at 20 °C

refractive index 

n20/D 1.464(lit.)

Flash point:

195 °F

storage temp. 

Store below +30°C.

solubility 

Acetonitrile (Slightly), Chloroform (Sparingly)

form 

Liquid

color 

Clear colorless to slightly yellow

Specific Gravity

1.200

PH

<7 (H2O, 20℃)

explosive limit

2.0-10.2%(V)

Water Solubility 

reacts

Sensitive 

Moisture Sensitive

BRN 

1745182

Stability:

Corrosive, Moisture Sensitive

InChIKey

SVNNWKWHLOJLOK-UHFFFAOYSA-N

CAS DataBase Reference

1575-61-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,T

Risk Statements 

22-34-23-23/34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 2

WGK Germany 

1

RTECS 

YV9108000

F 

10-19-21

HazardClass 

8

PackingGroup 

III

HS Code 

29159000

MSDS

• Language:English Provider:5-Chlorovaleryl chloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

5-Chlorovaleryl chloride Usage And Synthesis

Description

5-Chlorovaleryl chloride is an important synthetic intermediate of pyrazole herbicides. 5-Chloropentanoyl chloride is used as the raw material of 1,1,7-trichloro-1-hepten-3-one, and then the third-generation pyrazole herbicides can be synthesized. Pyrazole herbicides have the characteristics of ultra-efficient herbicidal activity, high selectivity, extremely low mammalian toxicity and good environmental characteristics, and have become a hot spot in the research and development of herbicides in the world in recent years.

Chemical Properties

clear colourless to slightly yellow liquid

Uses

5-Chlorovaleroyl chloride (5-CVC) has been used in the development and validation of a GC-FID method for the analysis of low level impurities present in 5-CVC. It has been used in the synthesis of anion-exchange resins by acylation of polystyrene/divinylbenzene and subsequent amination with trimethylamine. It is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.

Application

5-Chlorovaleryl chloride is an important medicine and pesticide intermediate. It is pharmaceutically mainly for the manufacture of the medicine Cilostazole (Cilostazol) for anti-platelet aggregation, protection of vascular endothelial cells, and atherosclerosis.5-Chlorovaleryl Chloride is also for the production of paddy rice New-type wide-spectrum weedicide pyraclonil (Pyraclonil).

General Description

5-Chlorovaleroyl chloride is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.

Flammability and Explosibility

Not classified

Synthesis

In the existing process, producing 5-Chlorovaleryl chloride using 1,4-dichlorobutane as raw material requires a three-step reaction. First, 1,4-dichlorobutane and sodium cyanide solution are combined to form 5-chlorovaleronitrile. Then, the prepared 5-chlorovaleronitrile is hydrolyzed in concentrated hydrochloric acid to form 5-chlorovaleric acid. Finally, 5-chlorovaleronitrile reacts with thionyl chloride to generate 5-chlorovaleryl chloride.

5-Chlorovaleryl chloride(1575-61-7)Related Product Information

• Choline chloride
• Valeryl chloride
• 2-Chloropropionyl chloride
• Ammonium chloride
• Pivaloyl chloride
• Sodium chloride
• Thionyl chloride
• 3-Chloropivaloyl chloride
• Calcium chloride
• 4-Chlorobenzenesulfonyl chloride
• Polyvinyl chloride
• Potassium chloride
• 4-Chlorobenzoyl chloride
• 4-Amino-3-nitrophenol
• Carbamic acid, N-[5-bromo-2-(trifluoromethyl)-4-pyridinyl]-, 1,1-dimethylethyl ester
• GLUTARYL DICHLORIDE
• HEXAFLUOROGLUTARYL CHLORIDE
• 5-Chlorovaleric acid