Neuraminidase Chemical Properties

Density 

1.00 g/mL at 20 °C

storage temp. 

2-8°C

form 

lyophilized powder

color 

white

Water Solubility 

Soluble in water or 10mM phosphate buffer, pH 6.0

EPA Substance Registry System

Neuraminidase (9001-67-6)

Safety Information

Safety Statements 

22-24/25

RIDADR 

UN3373 - class 6.2 Biological substance, Category B

WGK Germany 

3

RTECS 

QQ3450000

F 

3-10

TSCA 

Yes

MSDS

• Language:English Provider:SigmaAldrich

Neuraminidase Usage And Synthesis

Uses

Neuraminidase is used as a hydrolytic enzyme that removes sialic acid from mucoproteins, used in a study to assess binding with human T lymphocytes in sheep pretreated with neuraminidase. It has also been used in a study to investigate the effect of bile salts on the action of hydrolysis by neuraminidase.

Uses

Neuraminidase is an important deglycosylation enzyme capable of cleaving all non-reducing unbranched N-acetylneuraminic and N-glycolylneuraminic acid residues by hydrolysis of α(2→6), α(2→3), α(2→8), and α(2→9) linkages (affinity in the order given). Branched sialic acids may also be cleaved with the use of high concentrations of enzyme and prolonged incubations. Desialylated glycoproteins may then be further characterized by treatment with various exoglycosidases resulting in partial or complete O-deglycosylation. SDS-PAGE and MALDI-TOF MS are typically utilized in purification, structural analysis, and sequencing process. These techniques also remove heterogeneity and charge from the glycoprotein.

Uses

Neuraminidase from Vibrio cholera has been used in a study to describe a five-step purification method. It has also been used in a study to investigate modification of leukemia L1210 tumor cells.

General Description

Neuraminidase enzymes are glycoside hydrolase enzymes that catalyze hydrolysis of terminal sialic acid residues. The most well-known are the viral nearamidases, which promote influenza virus release.

Biochem/physiol Actions

Vibrio cholerae neuraminidase has been shown to promote cholera toxin infection by binding the toxin and aiding in its uptake by cells.

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