Diclofenac potassium Chemical Properties

Melting point:

300-330 °C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

Sparingly soluble in water, freely soluble in methanol, soluble in ethanol (96 per cent), slightly soluble in acetone.

form 

Solid

color 

White to off-white

CAS DataBase Reference

15307-81-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-51/53

Safety Statements 

61

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

HS Code 

2922492050

Diclofenac potassium Usage And Synthesis

Description

Dichlofenac potassium is the potassium salt of dichlofenac. It is a nonsteroidal anti-inflammatory agent that can be used to reduce inflammation and as an analgesic to reduce pain in certain conditions. It can also used to treat dysmenorrhea. It can treat inflammatory disorders such as musculoskeletal complaints, dental pain, arthritis, actinic keratosis, joint pain, acute pain and chronic pain caused by certain kinds of cancers. Traditional opinion proposes that diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. However, recent studies have shown that the pharmacologic activity of diclofenac goes beyond COX inhibition, and includes multimodal and, in some instances, novel mechanisms of action (MOA). For example, research suggests diclofenac can inhibit the thromboxane-prostanoid receptor, affect arachidonic acid release and uptake, inhibit lipoxygenase enzymes, and activate the nitric oxide–cGMP antinociceptive pathway. Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARγ), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.

References

Brogden, R. N., et al. "Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin." Drugs 20.1 (1980): 24-48.
Gan, Tong J. "Diclofenac: an update on its mechanism of action and safety profile." Current medical research and opinion 26.7 (2010): 1715-1731.
Riihiluoma, P., E. Wuolijoki, and M. O. Pulkkinen. "Treatment of primary dysmenorrhea with diclofenac sodium." European Journal of Obstetrics & Gynecology and Reproductive Biology 12.3 (1981): 189-194.

Chemical Properties

White or slightly yellowish, slightly hygroscopic, crystalline powder.

Uses

Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory.

Application

Diclofenac Potassium Salt is a nonsteroidal anti-inflammatory compound an decycloxygenase (COX) inhibitor.

Definition

ChEBI: The potassium salt of diclofenac.

brand name

Cataflam (Novartis).

Diclofenac potassium(15307-81-0)Related Product Information

• Potassium chloride
• Potassium Acetate
• Potassium phenylacetate
• Potassium sorbate
• Potassium iodide
• Potassium Citrate
• Potassium persulfate
• 3,4'-DIAMINODIPHENYLMETHANE
• 2-Hydroxyphenylacetic acid
• 1-(2,6-Dichlorophenyl)-2-indolinone
• 6-Aminocaproic acid
• Diclofenac sodium
• Glycine
• 2-AMINOPHENYLACETIC ACID
• Phenylphosphonic dichloride
• Dichloromethylphenylsilane
• 2-ANILINOPHENYLACETIC ACID
• 2,6-DICHLORODIPHENYLAMINE