BRAZILIN
BRAZILIN Basic information
- Product Name:
- BRAZILIN
- Synonyms:
-
- 2-d)pyran-3,6a,9,10(6h)-tetrol,7,11b-dihydro-benz(b)indeno(
- 6a,9,10(6h)-tetrol,7,11b-dihydro-2-d]pyran-(6as-cis)-benz[b]indeno[
- 7,11b-dihydrobenz(b)indeno(1,2-d)pyran-3,6a,9,10(6h)-tetrol
- brasilin
- braziletto
- hypernicextract
- limawoodextract
- pernambucoextract
- CAS:
- 474-07-7
- MF:
- C16H14O5
- MW:
- 286.28
- EINECS:
- 207-477-6
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Mol File:
- 474-07-7.mol
BRAZILIN Chemical Properties
- Melting point:
- 156-157℃
- Boiling point:
- 348.65°C (rough estimate)
- Density
- 1.1924 (rough estimate)
- refractive index
- 1.6200 (estimate)
- solubility
- DMSO:43.5(Max Conc. mg/mL);151.95(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);104.79(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);104.79(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);34.93(Max Conc. mM) - form
- A crystalline solid
- EPA Substance Registry System
- Brazilin (474-07-7)
Safety Information
- Safety Statements
- 24/25
- HS Code
- 29329990
BRAZILIN Usage And Synthesis
Description
Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Aβ (1-42) fibrillogenesis (IC50 = 1.5 μM) more potently than (-)-epigallocatechin gallate , cucurmin , and resveratrol (Item Nos. 10004235 | 70675). It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE2 and TNF-α (IC50s = 12.6 and 87.2 μM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 μg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.
Uses
Brazilin is a hair dyeing composition that comprises a natural dye and fatty amine.
Uses
Chiefly as a dye. Has also been recommended as indicator in acid-base titrations; acids = yellow, alkalies = carmine-red.
Uses
inhibits platelet aggregation, PLA2, PKC, protein phosphatase, insulin receptor kinase, nitric oxide synthase, antineoplastic
Definition
ChEBI: A organic heterotetracyclic compound that is a red pigment obtained from the wood of Caesalpinia echinata (Brazil-wood) or Caesalpinia sappan (sappan-wood).
Purification Methods
Brazilin crystallises from EtOH as yellow crystals which become orange when exposed to light and air, and is yellow in dilute acid but crimson in dilute alkali. When crystallised from H2O, it has m 247-248o. It forms coloured metal salts and is oxidized in air to Brazilein the quinonoid form. The (±)-form has been resolved, and the (+)-enantiomer has [] 20 +121o (c 1, MeOH). [Craig et al. J Org Chem 30 1573 1965,Morsingh & Robinson Tetrahedron 26 281 1970, Beilstein 17 H 194, 17 II 244, 17 III/IV 2711.]
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