CLASTO-LACTACYSTIN BETA-LACTONE
CLASTO-LACTACYSTIN BETA-LACTONE Basic information
- Product Name:
- CLASTO-LACTACYSTIN BETA-LACTONE
- Synonyms:
-
- OMURALIDE
- LACTACYSTIN, CLASTO-, BETA-LACTONE
- BETA-CLASTOLACTACYSTIN
- CLASTO-LACTACYSTIN BETA-LACTONE
- 1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
- clasto-lactacystin β-lactone
- Clasto-lactacystin (OMuralide)
- (1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
- CAS:
- 154226-60-5
- MF:
- C10H15NO4
- MW:
- 213.23
- Product Categories:
-
- Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases
- InhibitorsProtease Inhibitors
- Proteasome inhibitor
- Proteasome inhibitorEnzyme Inhibitors by Enzyme
- Intracellular Protein Degradation
- Nitric Oxide and Cell Stress
- P to
- Protease Inhibitor Specificity Index
- Proteasomes
- Inhibitors
- ProteasomeInhibitors
- Mol File:
- 154226-60-5.mol
CLASTO-LACTACYSTIN BETA-LACTONE Chemical Properties
- Melting point:
- 186-187°C
- storage temp.
- -20°C
- solubility
- DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine
- form
- White solid
- color
- White
Safety Information
- Hazard Codes
- T
- Risk Statements
- 20/21/22-37/38-41-36/37/38-25
- Safety Statements
- 16-26-36/37/39-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 2
MSDS
- Language:English Provider:SigmaAldrich
CLASTO-LACTACYSTIN BETA-LACTONE Usage And Synthesis
Chemical Properties
White Solid
Uses
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
Uses
Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.
Uses
clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.
Biological Activity
cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin
Biochem/physiol Actions
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcanii?by acting in the N-threonine residue of the? β -type subunits.
CLASTO-LACTACYSTIN BETA-LACTONESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- +1 (866) 930-6790
- info@adooq.com
- Tel
- +1-832-696-8203
- info@apexbt.com
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
CLASTO-LACTACYSTIN BETA-LACTONE(154226-60-5)Related Product Information
- 5-Hydroxymethylpyrrolidin-2-one
- 2-Methyl-D-serine
- (2R,3S)-(-)-2-Amino-3-hydroxy-4-methylpentanoic acid
- Ethyl D-(-)-pyroglutamate
- (S)-4-Hydroxy-2-pyrrolidinone
- CIS-3-HYDROXY-DL-PROLINE
- 2-Oxetanone
- BETA-BUTYROLACTONE
- D-Pyroglutamic acid
- DL-2-ISOBUTYLSERINE
- LACTACYSTIN
- dl-3-hydroxynorvaline
- 2-AMINO-3-HYDROXY-2-METHYLBUTANOIC ACID
- (2R,4R)-4-METHYL-2-PYROOLIDINE CARBOXYLIC ACID
- H-ALPHA-ME-D-LEU-OH
- 3-OXETANAMINE, 3-METHYL-
- H-ALPHA-ME-D-PRO-OH
- 3-OXETANAMINE