Triethylamine trihydrofluoride Chemical Properties

Melting point:

-29--27°C

Boiling point:

70 °C15 mm Hg(lit.)

Density 

0.989 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.3915(lit.)

Flash point:

190 °F

storage temp. 

Store below +30°C.

solubility 

soluble in Chloroform, Hexane

form 

Liquid

Specific Gravity

0.989

color 

Clear yellow to brown

PH

3 (H2O, 20℃)(saturated aqueous solution)

Water Solubility 

soluble

Sensitive 

Hygroscopic

BRN 

5522945

Exposure limits

ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3

CAS DataBase Reference

73602-61-6(CAS DataBase Reference)

EPA Substance Registry System

Ethanamine, N,N-diethyl-, trihydrofluoride (73602-61-6)

Safety Information

Hazard Codes 

T+,T,C,Xi,F

Risk Statements 

26/27/28-35-36/37/38-20/21/22-11

Safety Statements 

26-36/37/39-45-7/9-36/37-36-61-29-16-3

RIDADR 

UN 3265 8/PG 2

WGK Germany 

3

Hazard Note 

Corrosive

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29211910

MSDS

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Triethylamine trihydrofluoride Usage And Synthesis

Application

The t-butyldimethylsilyl (TBDMS) group is the most widely used 2'-OH protection in synthesis of oligoribonucleotides. The TBDMS-group became much used particularly after it was combined with phosphoroamidite methodology and was also the choice when H-phosphonate based RNA-synthesis was introduced. Removal of TBDMS-protection is most commonly done with 1 M tetrabutylammonium fluoride (TBAF) in tetrahydrofuran (THF). These conditions has proven efficient.

Chemical Properties

clear yellow liquid

Uses

Triethylamine trihydrofluoride acts as a mild and selective fluorinating agent used in the synthesis of acid fluorides and alkyl fluorides. It is also used in the synthesis of vicinal difluorides from epoxides, 3-fluoroazetidine. It is utilized as a selective reagent for the cleavage of O-silyl groups in carbohydrates, nucleotides and cyanohydrins. It is actively involved in the electrochemical fluorodeiodination of alkyl iodides and fluorodesilylation in beta-lactams.

Uses

Mild and selective reagent that has been used in the fluorination of a wide variety of compounds. For a review, see Aldrichimica Acta.

General Description

Triethylamine trihydrofluoride (TREAT-HF) is a mild and selective reagent for the fluorination of a wide variety of compounds.

Triethylamine trihydrofluoride(73602-61-6)Related Product Information

• Triethylamine
• Triethanolamine
• Triethyloxonium tetrafluoroborate
• TRIISOPROPYLSILYL TRIFLUOROMETHANESULFONATE
• TRIETHYL 2-PHOSPHONOBUTYRATE
• acetic acid, triethoxy-, ethyl ester
• triisopropylsilyl Methacrylate
• Triethylamine hydrochloride
• Tris(undecafluoropentyl)amine
• Perfluorotripropylamine
• Tetrabutylammonium hexafluorophosphate
• BENZYLTRIETHYLAMMONIUM TETRAFLUOROBORATE
• Triethylamine trihydrofluoride
• (S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE
• Tetrabutylammonium tetrafluoroborate
• Trifluoperazine dihydrochloride
• Tetraethylammonium hexafluorophosphate
• Hydrogen fluoride