Cinepazide
Cinepazide Basic information
- Product Name:
- Cinepazide
- Synonyms:
-
- CINEPAZIDE
- 1-(pyrrolidin-1-ylcarbonylmethyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine
- PIPERAZINE,1-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]-4-[1-OXO-3-(3,4,5-TRIMETHOXYPHENYL)-2-PROPENYL]
- 1-(1-Pyrrolidinylcarbonylmethyl)-4-[3-(3,4,5-trimethoxyphenyl)acryloyl]piperazine
- 1-[(1-Pyrrolidinylcarbonyl)methyl]-4-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]piperazine
- 2-Propen-1-one, 1-[4-[2-oxo-2-(1-pyrrolidinyl)ethyl]-1-piperazinyl]-3-(3,4,5-trimethoxyphenyl)-
- Cinepazide USP/EP/BP
- Cinepazide free base
- CAS:
- 23887-46-9
- MF:
- C22H31N3O5
- MW:
- 417.5
- EINECS:
- 245-928-9
- Mol File:
- 23887-46-9.mol
Cinepazide Chemical Properties
- Boiling point:
- 637.8±55.0 °C(Predicted)
- Density
- 1.200±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 5.22±0.10(Predicted)
- CAS DataBase Reference
- 23887-46-9(CAS DataBase Reference)
Cinepazide Usage And Synthesis
Uses
Cinepazide is an injection in the treatment of acute myocardial infarction and its effect on serum inflammatory factors.
Definition
ChEBI: Cinepazide is an olefinic compound. It is functionally related to a cinnamic acid.
World Health Organization (WHO)
Cinepazide, a vasodilating agent, was first introduced into medicine in 1974. It is used in the treatment of peripheral and cerebral vascular disorders. Following reports of blood dyscrasias, including agranulocytosis and thrombocytopenia, associated with the use of the drug, the Spanish Committee on Drug Surveillance has recommended its withdrawal. In other countries, the approved product information of preparations containing cinepazide has been amended to include a relevant warning on these adverse effects.
in vivo
Cinepazide (intravenous injection; 30 mg/kg) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP, while cinnarizine reduces their vasodilator effects[1]. Cinepazide (intravertebral injection; 1-10 mg/kg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by Aminophylline (HY-B0140) in dogs[1].
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Cinepazide(23887-46-9)Related Product Information
- 4-Methoxycinnamic acid
- 4-Methoxybenzoic acid
- p-Anisaldehyde
- p-Anisidine
- Piperazine
- Octyl 4-methoxycinnamate
- Ethyl 4-methoxycinnamate
- Anisole
- (Trifluoromethoxy)benzene
- CINEPAZIDE MALEATE
- 1-((PYRROLIDINE-1-CARBONYL)METHYL)PIPERAZINE
- 1-(2-PYRROLIDINOETHYL)PIPERAZINE
- Cintramide
- 1-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]ETHANONE
- N,N-DIETHYL-2-PIPERAZIN-1-YL-ACETAMIDE
- 1-CINNAMOYL-PIPERAZINE
- Cinepazide
- 1-[3-(4-HYDROXY-3-METHOXYPHENYL)-OXO-2-PROPENYL]-PIPERAZINE