Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Analytical Chemistry >  Standard >  Volatile organic compounds (VOCs) >  3-(4-METHYLBENZYLIDENE)CAMPHOR

3-(4-METHYLBENZYLIDENE)CAMPHOR

Basic information Safety Supplier Related

3-(4-METHYLBENZYLIDENE)CAMPHOR Basic information

Product Name:
3-(4-METHYLBENZYLIDENE)CAMPHOR
Synonyms:
  • 4''-METHYLBENZYLIDENE CAMPHOR(MBC 95)
  • NEO-HELIOPAN
  • METHYLBENZYLIDENECAMPHOR
  • MEXORYLSD
  • 3-(4-METHYLBENZYLIDINE)CAMPHOR
  • (+-)-1,7,7-Trimethyl-3-[(4-methylphenyl)methylen]bicyclo[2.2.1]heptan-2-on
  • (1S,2Z,4R)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]-3-bicyclo[2.2.1]heptanone
  • (2Z)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one
CAS:
36861-47-9
MF:
C18H22O
MW:
254.37
EINECS:
253-242-6
Product Categories:
  • Aromatics
  • Intermediates & Fine Chemicals
  • cosmetic raw material
  • UV-Absorber
  • Pharmaceuticals
Mol File:
36861-47-9.mol
More
Less

3-(4-METHYLBENZYLIDENE)CAMPHOR Chemical Properties

Melting point:
66-68°C
Boiling point:
198-200 °C
Density 
1.064±0.06 g/cm3(Predicted)
RTECS 
DT5099565
storage temp. 
Inert atmosphere,Room Temperature
solubility 
insoluble in H2O; ≥10 mg/mL in DMSO; ≥111.2 mg/mL in EtOH
form 
Solid
color 
White to off-white
BRN 
9213949
LogP
3.385 (est)
CAS DataBase Reference
36861-47-9(CAS DataBase Reference)
EPA Substance Registry System
Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-3-[(4-methylphenyl)methylene]- (36861-47-9)
More
Less

Safety Information

Hazard Codes 
Xn
Risk Statements 
63
Safety Statements 
22-24/25-36/37
WGK Germany 
2
TSCA 
Yes
HS Code 
2914399000

MSDS

  • Language:English Provider:ALFA
More
Less

3-(4-METHYLBENZYLIDENE)CAMPHOR Usage And Synthesis

Chemical Properties

White Solid

Uses

3-(4-Methylbenzyliden)camphor is an UV-B absorbing agent in sunscreen cosmetics of the type creams, lotions, lipsticks, sun oils, etc.

Uses

3-(4-Methylbenzylidene)camphor is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. 4-Methylbenzylidene camphor(4-MBC) a UV-B ray filter, is an endocrine disruptors (ED).

Uses

4-(Methylbenzylidene)camphor (4-MBC), a UV-B ray filter, is an endocrine disruptors (ED).

Biological Activity

4-methylbenzylidene camphor (4-mbc) is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.since the estrogen receptor (er) ligand type can influence transactivation, it is important to obtain information on molecular actions of nonclassical er agonists.

in vitro

previous results of competitive binding assays using cytosolic protein preparations from xenopus hepatocytes demonstrated that 4-mbc could weakly bind to the er. in addition, 4-mbc at a 100 micromol/l was not able to replace estradiol from the receptor completely [1].

in vivo

the estrogen target gene expression in uterus of long evans rats after exposure to 4-mbc was studied. results showed that 4-mbc could altere steady-state levels of mrnas encoding for er, progesterone receptor (pr), and androgen recepto in uterus of 12-wk-old offspring. to evaluate sensitivity to estradiol (e2), offspring were injected with e2, and killed 6 h later. acute up-regulation of pr and igf-i and down-regulation of er and androgen receptor by e2 were reduced in 4-mbc treated rats dose-dependently [2].

References

[1] klann a, levy g, lutz i, müller c, kloas w, hildebrandt jp. estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells. environ res. 2005 mar;97(3):274-81.
[2] s. durrer, k. maerkel, m. schlumpf, et al. estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. endocrinology 146(5), 2130-2139 (2005).
[3] n. r. janjua, b. mogensen, a. m. andersson, et al. systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. journal of investigative dermatology 123, 57-61(2004).

3-(4-METHYLBENZYLIDENE)CAMPHORSupplier

Jiangxi Lotchem Co., Ltd. Gold
Tel
0791-0791-85061535 15270827708
Email
lancetu@jxlotchem.com
Hangzhou Lin'an tianhong biotechnology co.,ltd. Gold
Tel
0571-58605786 15957158331
Email
hu@tianhongsw.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Email
market03@meryer.com
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Email
sales@BioChemBest.com