2-PYRAZINECARBONYL CHLORIDE Chemical Properties

Melting point:

41°C

Boiling point:

214.5±20.0 °C(Predicted)

Density 

1.393±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-2.50±0.10(Predicted)

Water Solubility 

Reacts with water.

Sensitive 

Moisture Sensitive

CAS DataBase Reference

19847-10-0(CAS DataBase Reference)

Safety Information

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

3265

HazardClass 

8

PackingGroup 

II

HS Code 

2933998090

MSDS

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2-PYRAZINECARBONYL CHLORIDE Usage And Synthesis

Uses

2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

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