Eprazinone dihydrochloride Chemical Properties

Melting point:

201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Safety Information

Toxicity

LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher)

Eprazinone dihydrochloride Usage And Synthesis

Originator

Mucitux,Riom,France,1969

Uses

Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.

Definition

ChEBI: A hydrochloride obtained by combining eprazinone with two molar equivalents of hydrochloric acid.

Manufacturing Process

61.4 g of 0.2M of 1-(2-phenyl-2-ethoxy)piperazine dihydrochloride, 33.5 g (0.25M) propiophenone, 75 g (0.25M) trioxymethylene, 120 ml of ethanol and 0.4 ml of concentrated HCl are heated under reflux for 4 to 5 hours. The product is allowed to crystallize, then filtered and washed with alcohol. It is dried and recrystallized from methanol containing 10% H2O.
There is thus obtained 60 g of a white crystalline powder soluble in water. Yield: 66%. Melting point: 160°C.

Therapeutic Function

Antitussive

Eprazinone dihydrochloride(10402-53-6)Related Product Information

• Eprazinone
• Methyl acetate
• Ethoxyamine hydrochloride
• Ipriflavone
• Ethoxyethyne
• METSULFURON METHYL
• Ethoxyquin
• Kresoxim-methyl
• DIETHOXYMETHANE
• Tribenuron methyl
• Piperazine
• Thiophanate-methyl
• Methyl salicylate
• Dihydrochloride
• Methyl
• Methyl bromide
• 1-(3-PHENYLPROPYL)PIPERAZINE
• 1-(2-PHENYLETHYL)PIPERAZINE