SC 19220 Chemical Properties

Melting point:

190-191 °C (lit.)

storage temp. 

Store at RT

solubility 

DMSO: 10 mg/mL, soluble

form 

solid

color 

white

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

SC 19220 Usage And Synthesis

Uses

SC 19220 is a selective EP1?receptor antagonist.

Uses

SC 19220 was used to study the role of prostaglandin E₂ in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.

Definition

ChEBI: N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide is an aromatic ether.

Biological Activity

Selective EP 1 receptor antagonist (IC 50 = 6.7 μ M for inhibition of [ 3 H]-PGE 2 binding to EP 1 transfected COS cells).

Biochem/physiol Actions

SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.

storage

Store at RT

SC 19220(19395-87-0)Related Product Information

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