METHYL 3-METHOXY-4-METHYLBENZOATE Chemical Properties

Melting point:

50-54 °C (lit.)

Boiling point:

119-120°C 1mm

Density 

1.075±0.06 g/cm3(Predicted)

refractive index 

1.5295

Flash point:

>230 °F

form 

powder to crystal

color 

White to Almost white

BRN 

1948339

CAS DataBase Reference

3556-83-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

1

HS Code 

29189900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

METHYL 3-METHOXY-4-METHYLBENZOATE Usage And Synthesis

Preparation

Methyl 3-methoxy-4-methylbenzoate is synthesized by the following steps:A mixture of methyl 3-hydroxy-4-methylbenzoate 36 (25 g, 0.151 mol),  Me2SO4 (28.3 ml, 0.386 mol), anhydrous K2CO3 (103.5 g, 0.75 mol) was  refluxed in acetone for 2 hours. K2CO3 was filtered off, washed  thoroughly with acetone. The filtrates were combined and concentrated,  the residue was redissolved in EtOAc washed with water, dried  (anhydrous Na2SO4), filtered and concentrated in vacuo to furnish a white solid (19.52 g).  Yield : 72%.

Chemical Properties

White low melting solid

Uses

Methyl 3-Methoxy-4-methylbenzoate has been used as a reactant in the preparation of an antimalaria drug that consists of the 4-aminoquinoline pharmacophore of chloroquine with clotrimazole-based antimalarials.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 1771, 1990 DOI: 10.1021/jm00168a036

General Description

Methyl 3-methoxy-4-methylbenzoate can be prepared by reacting diazomethane with 3-methoxy-4-methylbenzoic acid in ether.

METHYL 3-METHOXY-4-METHYLBENZOATE(3556-83-0)Related Product Information

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• Methyl 3-methyl-5-(trifluoromethyl)benzoate
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• METHYL 5-BROMO-2-METHOXY-3-METHYLBENZENECARBOXYLATE
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