GANODERIC ACID A Chemical Properties

Melting point:

118～123℃

Boiling point:

690.1±55.0 °C(Predicted)

Density 

1.22

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Chloroform (Slightly, Sonicated), Methanol (Slightly)

form 

Solid

pka

4.78±0.23(Predicted)

color 

White to Pale Yellow

InChIKey

OVUOUFPIPZJGME-YYJACZGBNA-N

SMILES

[C@@]12(C)[C@@H](O)C[C@H](/C(/C)=C/C(=O)CC(C)C(O)=O)[C@@]1(C)CC(=O)C1[C@@]3([C@]([H])(C(C)(C)C(CC3)=O)C[C@H](O)C2=1)C |&1:0,2,5,17,23,24,34,r|

Safety Information

Safety Statements 

24/25

HS Code 

29189900

GANODERIC ACID A Usage And Synthesis

Description

Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities. It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells. Ganoderic acid A (2-100 μg/ml) reduces hypoxia-induced apoptosis in H9c2 cardiomyocytes. It inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia. Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-κB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury. It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity.

Chemical Properties

White powder

Uses

Ganoderic Acid A, is a new lanostanoid triterpene extracted from the fruit bodies of Ganoderma Lucidum mushroom. these compounds are shown to possess many therapeutic properties. They can be used as anti-virus, anti-inflammation, anti-tumor, immunity-promoting, anti-diabetic, etc.

Definition

ChEBI: Ganoderic acid A is a triterpenoid.

in vivo

References

[1] B. S. GILL N Sanjeev Kumar. Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer[J]. Molecular Biology Reports, 2016, 43 1: 1411-1422. DOI: 10.1007/s11033-016-4074-z
[2] BAOJIN CHI. Effects of ganoderic acid A on lipopolysaccharide-induced proinflammatory cytokine release from primary mouse microglia cultures.[J]. Experimental and therapeutic medicine, 2018, 15 1: 847-853. DOI: 10.3892/etm.2017.5472
[3] BING WAN. Ganoderic acid A attenuates lipopolysaccharide-induced lung injury in mice.[J]. Bioscience Reports, 2019. DOI: 10.1042/bsr20190301
[4] JING ZHU . Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway[J]. Chemico-Biological Interactions, 2018, 290: Pages 77-87. DOI: 10.1016/j.cbi.2018.05.014

GANODERIC ACID A(81907-62-2)Related Product Information

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