GANODERIC ACID A Chemical Properties

Melting point:

118～123℃

Boiling point:

690.1±55.0 °C(Predicted)

Density 

1.22

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Chloroform (Slightly, Sonicated), Methanol (Slightly)

form 

Solid

pka

4.78±0.23(Predicted)

color 

White to Pale Yellow

Safety Information

Safety Statements 

24/25

HS Code 

29189900

GANODERIC ACID A Usage And Synthesis

Description

Ganoderic acid A is a triterpene that has been found in Ganoderma and has diverse biological activities. It reduces cell viability, expression of superoxide dismutase 1 (SOD1), SOD2, and SOD3, and production of reactive oxygen species (ROS) in PC3 prostate cancer cells. Ganoderic acid A (2-100 μg/ml) reduces hypoxia-induced apoptosis in H9c2 cardiomyocytes. It inhibits LPS-induced activation of NF-κB, release of TNF-α, IL-1β, and IL-6, and mitochondrial activity in primary mouse cortical microglia. Ganoderic acid A (20 and 40 mg/kg) reduces lung myeloperoxidase (MPO) activity, neutrophil infiltration, and NF-κB signaling, as well as bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-1β, and IL-6 in a mouse model of LPS-induced lung injury. It also reduces weight gain and hepatic lipid accumulation and improves insulin sensitivity in a mouse model of high-fat diet-induced obesity.

Chemical Properties

White powder

Uses

Ganoderic Acid A, is a new lanostanoid triterpene extracted from the fruit bodies of Ganoderma Lucidum mushroom. these compounds are shown to possess many therapeutic properties. They can be used as anti-virus, anti-inflammation, anti-tumor, immunity-promoting, anti-diabetic, etc.

Definition

ChEBI: Ganoderic acid A is a triterpenoid.

GANODERIC ACID A(81907-62-2)Related Product Information

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