H-PRO-NME2 Chemical Properties

Boiling point:

250.2±29.0 °C(Predicted)

Density 

1.017±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

9.18±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

29802-22-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36

Safety Statements 

26

HS Code 

2933998090

H-PRO-NME2 Usage And Synthesis

Uses

L-Proline Dimethylamide is a reactant used in the synthesis of fluoromethylsulfonylaminophenyl propanamides as TRPV1 antagonists.

Synthesis

Take a clean beaker, add 180 mL of tetrahydrofuran solution, weigh and prepare N,N-dimethylpyrrolidine-2-carbonyl chloride dissolved in tetrahydrofuran, after dissolution, the solution was slowly added to the ice-water bath under the conditions of the dimethylamine tetrahydrofuran (which had been loaded into the clean three reaction flasks), the solid was precipitated immediately, and after addition, the stirring was continued for 4 hours at 35 ??, and the progress of the reaction was detected by thin-layer chromatography. After the reaction was completed and the reaction solution was cooled, 400 mL of ice water was added to the reaction, so that the product was completely precipitated, and a light yellow solid was obtained by filtration. After drying and recrystallization with anhydrous acetone, N,N-dimethylpyrrolidine-2-carboxamide was obtained.

H-PRO-NME2(29802-22-0)Related Product Information

• ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-D-PRO-NME-LEU-TRP-NH2
• Boc-L-Pro-NMe(OMe)
• BOC-PRO-NME(OME)
• H2H-(CH2)4-CO-PHE-PRO-NME-LEU-MET-NH2
• TYR-PRO-(NME)PHE-DPRO-NH2
• AC-LEU-PRO-(NME-PHE)-PHE-ASP-NH2