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ATRACTYLOSIDE POTASSIUM SALT

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ATRACTYLOSIDE POTASSIUM SALT Basic information

Product Name:
ATRACTYLOSIDE POTASSIUM SALT
Synonyms:
  • ATR, 2K
  • ATRACTYLOSIDE, DIPOTASSIUM SALT
  • ATRACTYLOSIDE, DIPOTASSIUM SALT, ATRACTYLIS GUMMIFERA
  • ATRACTYLOSIDE POTASSIUM SALT
  • 19-Norkaur-16-en-18-oic acid, 15-hydroxy-2-2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-.beta.-D-glucopyranosyloxy-, dipotassium salt, (2.beta.,15.alpha.)-
  • (2beta,15alpha)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic acid dipotassium salt
  • 19-Norkaur-16-en-18-oicacid, 15-hydroxy-2-[[2-O-(3-Methyl-1-oxobutyl)-3,4-di-O-sulfo-b-D-glucopyranosyl]oxy]-,dipotassiuM salt, (2b,15a)- (9CI)
  • Atractyloside dipotassium salt, >=98%
CAS:
102130-43-8
MF:
C30H47KO16S2
MW:
766.91
Product Categories:
  • reagent
  • standard substance
  • chemical reagent
  • herbal extract
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • Cell Stress
  • Mitochondrial Inhibitors
  • Nitric Oxide and Cell Stress
Mol File:
102130-43-8.mol
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ATRACTYLOSIDE POTASSIUM SALT Chemical Properties

Melting point:
234-238°C
storage temp. 
Sealed in dry,2-8°C
solubility 
H2O: 20 mg/mL
form 
Solid
color 
Pale Brown to Pale Beige
Stability:
Hygroscopic
InChIKey
VFOXXOVBJAYRTD-GYBHJGEKNA-N
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37-45
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
2938909090

MSDS

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ATRACTYLOSIDE POTASSIUM SALT Usage And Synthesis

Description

Atractyloside is a natural heteroglucoside produced in some plants, including A. gummifera. Atractyloside prevents mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di- and triphosphates across the inner mitochondrial membrane.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Xanthium sibiricum, Atractylodes lancea, and Atractylodes macrocephala.

Uses

Atractyloside Dipotassium Salt is an inhibitor of ANT and apoptosis inducer.

in vivo

Atractyloside (2-4 mg/kg, i.p., 2 weeks before feeding duration ends) potassium salt protects mice against liver steatosis by activation of autophagy via ANT-AMPK-mTORC1 signaling pathway[13].
Atractyloside (50 mg/kg, i.p.) potassium salt produces a tubular nephrosis 180 min after its administration in male albino rats[14].

Animal Model:Male ICR wide-type (WT) mice (feed with a high-fat diet (HFD))[13]
Dosage:2, 4 mg/kg
Administration:Intraperitoneal injection (i.p.), 2 weeks before the feeding duration ends
Result:Reversed the changes of body weight, RW of liver and epididymal fat, and the serum AST level.
Improved the NAFLD steatosis and decrease HFD-induced lipid accumulation in the liver.
Decreased the protein expression of p-mTOR and the value of p-mTOR/mTOR.
Increased the protein expression of LC3A/B-Ⅱ and ATG7.
Increased amount of colocalization of LC3B and PLIN2.

References

[1]. yamaguchi n, kagari t, kasai m. inhibition of the ryanodine receptor calcium channel in the sarcoplasmic reticulum of skeletal muscle by an adp/atp translocase inhibitor, atractyloside. biochem biophys res commun, 1999, 258(2): 247-251.
[2]. pick-kober kh, schneider f. proliferation, macromolecular synthesis and energy metabolism of in vitro grown ehrlich ascites tumor cells after inhibition of atp-adp translocation by atractyloside. eur j cell biol, 1984, 34(2): 323-329.
[3]. malekova l, kominkova v, ferko m, et al. bongkrekic acid and atractyloside inhibits chloride channels from mitochondrial membranes of rat heart. biochim biophys acta, 2007, 1767(1): 31-44.

ATRACTYLOSIDE POTASSIUM SALTSupplier

Jiangxi Baicaoyuan Biotechnology Co. , Ltd. Gold
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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Chengdu Climax Biotech Co., Ltd.
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028-83311324 1278112614
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Shanghai Winherb Medical Technology Co., Ltd.
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021-38218169 13341702378
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