Ethyl 2-isopropylacetoacetate Chemical Properties

Boiling point:

82-85 °C/12 mmHg (lit.)

Density 

0.962 g/mL at 20 °C (lit.)

refractive index 

n20/D 1.425

Flash point:

76 °C

storage temp. 

2-8°C

solubility 

Chloroform, Ethyl Acetate

form 

Oil

pka

12.28±0.46(Predicted)

color 

Clear Colorless

BRN 

636360

LogP

1.584 (est)

CAS DataBase Reference

1522-46-9(CAS DataBase Reference)

NIST Chemistry Reference

Butanoic acid, 2-acetyl-3-methyl-, ethyl ester(1522-46-9)

EPA Substance Registry System

Ethyl 2-isopropylacetoacetate (1522-46-9)

Safety Information

Safety Statements 

23-24/25

WGK Germany 

3

HS Code 

2918300090

MSDS

• Language:English Provider:Ethyl 2-isopropylacetoacetate
• Language:English Provider:SigmaAldrich

Ethyl 2-isopropylacetoacetate Usage And Synthesis

Description

Ethyl 2-isopropylacetoacetate is a β-keto ester compound with an isopropyl substitution at the α-position between the two carbonyls. It is potentially useful as in synthetic applications as a precursor to α,α-disubstituted β-keto esters, and the α-Me and α-Et analogs have been used in the preparation of stereodefined α,α-disubstituted amino acids.

Uses

Ethyl 2-Isopropylacetoacetate is a reactant in the preparation of nonracemic arylhydroxymethylpyrrolidinylmethylphenyl thiazoleacetamides and cyclopentathiazolecarboxamides as conformationally restricted β3-adrenoceptor agonists as a potential treatment for overactive bladder.

Ethyl 2-isopropylacetoacetate(1522-46-9)Related Product Information

• Ethyl acetoacetate
• Ethyl 4,4,4-trifluoroacetoacetate
• Ethyl 4-chloroacetoacetate
• N-Acetyl-L-cysteine
• Ethyl 4-bromoacetoacetate
• Ethanol
• Acetylacetone
• Ethyl propionate
• N-ACETYL-L-TYROSINE ETHYL ESTER
• Ethyl acetate
• Ethyl 2-methylacetoacetate
• Ethyl butyrate
• Ethyl formate
• tert-Butyl acetoacetate
• Isopropyl acetoacetate
• Ethylparaben
• Methyl acetoacetate
• Acetyl coenzyme A sodium salt