2-Tetrahydrofuroic acid Chemical Properties

Melting point:

21°C

Boiling point:

128-129 °C13 mm Hg(lit.)

Density 

1.209 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.46(lit.)

Flash point:

139 °C

storage temp. 

Sealed in dry,2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

3.60±0.20(Predicted)

form 

Liquid

color 

Clear yellow to brown

Water Solubility 

soluble

BRN 

109671

CAS DataBase Reference

16874-33-2(CAS DataBase Reference)

NIST Chemistry Reference

2-Furancarboxylic acid, tetrahydro-(16874-33-2)

EPA Substance Registry System

2-Furancarboxylic acid, tetrahydro- (16874-33-2)

Safety Information

Hazard Codes 

C

Risk Statements 

22-34

Safety Statements 

26-36/37/39-45-28A

RIDADR 

UN 3265 8/PG 3

WGK Germany 

3

HazardClass 

8

PackingGroup 

III

HS Code 

29321900

MSDS

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2-Tetrahydrofuroic acid Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

2-Tetrahydrofuroic acid is used as a reagent to synthesize Alfuzosin (HCl: A532000), an unselective alpha-1 blocker that is used to treat lower urinary tract symptoms and benign prostatic hyperplasia.

General Description

Tetrahydro-2-furoic acid inhibits the programmed cell death of Xanthomonas campestris strains. It is a specific inhibitor of proline dehydrogenase, a mitochondrial flavoenzyme that oxidizes proline.

2-Tetrahydrofuroic acid(16874-33-2)Related Product Information

• 2-Methyltetrahydrofuran
• 2-Furoic acid
• Tetrahydrofuran
• Folic acid
• Mometasone furoate
• Citric acid
• Ethyl 2-(Chlorosulfonyl)acetate
• TETRAHYDRO-3-FUROIC ACID
• Terazosin impurity
• 2-Piperazine-4-amino-6,7-dimethoxyquinazoline
• (R)-Terazosin
• 2,2'-(1,4-Piperazinediyl)bis[6,7-diMethoxy-4-quinazolinaMine]
• 1-[4-(4-AMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl]-5-hydroxy-1-pentanone
• 6,7-DiMethoxy-2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)quinazolin-4(1H)-one
• Terazosin EP IMpurity D
• [4-(4-AMino-7-hydroxy-6-Methoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)Methanone
• NSC 351869
• 1-(2-Furoyl)piperazine