Dehydronandrolone Acetate Chemical Properties

Melting point:

95-98?C

Boiling point:

457.4±45.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

Controlled Substance, -20°C Freezer

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

Off-White to Pale Yellow

InChI

InChI=1/C20H26O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h3,5,11,15-19H,4,6-10H2,1-2H3/t15-,16+,17+,18-,19-,20-/s3

InChIKey

OGUASZAAVFYYIL-SBVYDUMINA-N

SMILES

[C@@]12([H])CC[C@H](OC(=O)C)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3C=C[C@@]21[H] |&1:0,4,9,13,15,25,r|

CAS DataBase Reference

2590-41-2(CAS DataBase Reference)

Dehydronandrolone Acetate Usage And Synthesis

Description

Dehydronandrolone acetate is a critical precursor in the synthesis of C7-functionalized steroidal drugs such as the new anti-breast cancer drug Fulvestrant, the treatment of menopause and postmenopausal syndrome drug Tibolone, as well as the highly effective protein anabolic hormone Mibolone. Nandrolone as starting material was first subjected to simultaneous acylation with acetic anhydride and acetyl chloride to form the intermediate, which was then brominated with N-bromosuccinimide (NBS) under basic conditions to eliminate one molecule of HBr to produce Dehydronandrolone acetate (73% yield)[1].

Chemical Properties

Pale Yellow Solid

Uses

Tibolone intermediate.

References

[1] Zili Zhang and Aitao Li*. “A Designed Chemoenzymatic Route for Efficient Synthesis of 6-Dehydronandrolone Acetate: A Key Precursor in the Synthesis of C7-Functionalized Steroidal Drugs.” ACS Catalysis 13 19 (2023): 13111–13116.

Dehydronandrolone Acetate(2590-41-2)Related Product Information

• 2-Butoxyethyl acetate
• Ethylene glycol monoethyl ether acetate
• Isopropyl acetate
• Tocopheryl acetate
• 1-Methoxy-2-propyl acetate
• Mestanolone
• Nandrolone Decanoate
• Metenolone
• Stanolone
• Fulvestrant
• Zinc chloride
• Exemestane
• ALTRENOGEST
• 6-DEHYDRONANDROLONE
• Ethyl 2-(Chlorosulfonyl)acetate
• Nandrolone
• (7Z,9E)-dodeca-7,9-dienyl acetate
• Dehydronandrolone Acetate