4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL Chemical Properties

Melting point:

145-148 °C (lit.)

Boiling point:

383.9±37.0 °C(Predicted)

Density 

1.307±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

13.59±0.10(Predicted)

color 

White to Yellow to Green

Water Solubility 

Soluble in water.

λmax

400nm(CH3CN)(lit.)

Sensitive 

Light Sensitive

BRN 

1880093

CAS DataBase Reference

1016-58-6(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

8

HazardClass 

IRRITANT

HS Code 

29094990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

4,5-Dimethoxy-2-nitrobenzyl alcohol, is used as Reagent for the protection of alcohols, etc., as ethers which can be cleaved by photolysis involving intramolecular rearrangement to derivatives of o-nitrosobenzaldehyde, which are readily cleaved by hydrolysis. It is also used as photochemical protecting groups in organic synthesis. It is also used as a pharmaceutical intermediate.

Uses

4,5-Dimethoxy-2-nitrobenzyl alcohol (6-nitroveratryl alcohol) is suitable reagent used in the synthesis of 4,5-dimethoxy-2-nitrobenzyl methacrylate, a photolabile monomer and 2-(4-((4-(4,5-dimethoxy-2-nitrobenzyloxy)phenyl)cyclohexylidene)methyl)phenoxy)-N,N-dimethylethanamine, a caged cyclofen-OH ligand.

It may be used in the synthesis of the following:

• 1-[[(chlorocarbonyl)oxy]methyl]-4,5-dimethoxy-2-nitrobenzene
• bis(4,5-dimethoxy-2-nitrophenyl)ethylene glycol, a photolabile protecting group
• optically-sensitive monomer
• nitroveratryl (NV) protected α-hydroxyacetic acid (αG) (NV-αG-OH), required in the preparation of nitroveratryl (NV) protected cyanomethyl (CM) ester of α-hydroxyacetic acid (αG) (NV-αG-CM)
• 4,5-dimethoxy-2-nitrobenzyl p-nitro-phenylcarbonate
• 6-nitroveratryloxycarbonyl chloride (NVOCCl), a reagent used in the protection of amino function in amino sugars

General Description

4,5-Dimethoxy-2-nitrobenzyl alcohol (6-Nitroveratryl Alcohol) is 2-nitrobenzyl alcohol derivative. It has been reported to be one of the oxidation products of veratryl (3,4-dimethoxybenzyl) alcohol by lignin peroxidase (isolated from Phanerochaete chrysosporium).

4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL(1016-58-6)Related Product Information

• Methyl 2-nitro-3,4,5-trimethoxybenzoate
• 4,5-DIMETHOXY-2-NITROBENZYL ALCOHOL
• 6-NITROVERATRYL CHLOROFORMATE
• 4-[4-(1-Hydroxyethyl)-2-Methoxy-5-nitrophenoxy]butanoic Acid
• ETHYL 4,5-DIMETHOXY-2-NITROBENZOATE
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• D-ribo-Hexanoic acid, 3-deoxy-, γ-lactone
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• GLUTAMATE, CAGED
• 4,5-DIMETHOXY-2-NITROBENZYL ADENOSINE 3',5'-CYCLICMONOPHOSPHATE
• 4-(4-HYDROXYMETHYL-2-METHOXY-5-NITROPHENOXY)BUTYRIC ACID
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• 3,4,5-TRIMETHOXY-2-NITROBENZOIC ACID
• D-LUCIFERIN 1-(4,5-DIMETHOXY-2-NITROPHENYL)ETHYL ESTER
• ARACHIDONIC ACID 1-(4,5-DIMETHOXY-2-NITROPHENYL)ETHYL ESTER
• ADENOSINE 5'-TRIPHOSPHATE, P3-(1-(4,5-DIMETHOXY-2-NITROPHENYL)ETHYL) ESTER, DISODIUM SALT
• A-23187, 1-(4,5-DIMETHOXY-2-NITROPHENYL)ETHYL ESTER
• 4-BROMO A-23187, 1-(4,5-DIMETHOXY-2-NITROPHENYL)ETHYL ESTER