NICOTINIC ACID HYDROCHLORIDE
NICOTINIC ACID HYDROCHLORIDE Basic information
- Product Name:
- NICOTINIC ACID HYDROCHLORIDE
- Synonyms:
-
- NICOTINIC ACID HYDROCHLORIDE
- Pyridine-3-carboxylic acid hydrochloride
- Niacin hydrochloride
- CAS:
- 636-79-3
- MF:
- C6H6ClNO2
- MW:
- 159.57
- Mol File:
- 636-79-3.mol
NICOTINIC ACID HYDROCHLORIDE Chemical Properties
- Melting point:
- 250-255 °C
- EPA Substance Registry System
- 3-Pyridinecarboxylic acid, hydrochloride (636-79-3)
NICOTINIC ACID HYDROCHLORIDE Usage And Synthesis
Uses
Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2].
in vivo
Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3].
| Animal Model: | Male C57BL/6 mice[3] |
| Dosage: | 3-300 mg/kg |
| Administration: | Subcutaneous injection; once |
| Result: | Induced vasodilation in a dose-dependent manner. |
IC 50
Microbial Metabolite; Human Endogenous Metabolite
References
[1] Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18. DOI:10.1016/j.theriogenology.2021.04.005
[2] Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8. DOI:10.1271/bbb.69.653
[3] Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7. DOI:10.1073/pnas.0601574103
NICOTINIC ACID HYDROCHLORIDE(636-79-3)Related Product Information
- 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID
- 6-Chloronicotinic acid
- 7-CHLORO-4-HYDROXY QUINOLINE-3-CARBOXYLIC ACID
- TRIGONELLINE HYDROCHLORIDE
- 2-(4-CHLOROPHENOXY)NICOTINIC ACID
- 2-(4-CHLOROPHENYLTHIO)NICOTINIC ACID
- Methyl 6-chloronicotinate
- 2-Chloronicotinic acid
- 2,6-Dichloronicotinic acid
- 4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
- 3,4,5-Trifluorobenzaldehyde
- 5,6-Dichloronicotinic acid
- ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE
- 5-Chloro-6-hydroxy-3-pyridinecarboxylic acid
- 1,2,5,6-TETRAHYDRO-1-METHYL-NICOTINIC ACID HYDROCHLORIDE
- 6-AMINO-NICOTINIC ACID HYDROCHLORIDE
- 4-CHLORO-5,8-DIFLUOROQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER
- ETHYL 4-(3,5-DICHLOROPHENOXY)-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE