2-AMINO-5-METHYLBENZAMIDE Chemical Properties

Melting point:

178-180°C

Boiling point:

265.7±28.0 °C(Predicted)

Density 

1.185±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

15.88±0.50(Predicted)

form 

solid

Appearance

Off-white to light yellow Solid

CAS DataBase Reference

40545-33-3(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38-36

Safety Statements 

26-36/37/39

2-AMINO-5-METHYLBENZAMIDE Usage And Synthesis

Synthesis

Step 2: 5-Methyl-2-nitrobenzamide (15.0 g, 83.3 mmol) was dissolved in methanol (300 mL) and 10% palladium carbon catalyst (2.50 g) was added. The reaction was stirred for 12 hours under hydrogen atmosphere (1 atmosphere) and room temperature. After completion of the reaction, the insoluble material was removed by filtration and the filtrate was concentrated to afford 2-amino-5-methylbenzamide (12.4 g, 99% yield) in white powder form.

References

[1] Patent: EP1953148, 2008, A1. Location in patent: Page/Page column 130
[2] Patent: US2015/329556, 2015, A1. Location in patent: Paragraph 1532
[3] Journal of Medicinal Chemistry, 1992, vol. 35, # 14, p. 2626 - 2630
[4] Patent: US5234925, 1993, A
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2786 - 2796

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