DOTA Chemical Properties

Melting point:

267 °C

Boiling point:

701.6±60.0 °C(Predicted)

Density 

1.321

storage temp. 

Sealed in dry,Room Temperature

solubility 

Water (Slightly, Heated), Methanol (Slightly)

pka

2.16±0.10(Predicted)

form 

Powder

color 

white

BRN 

1186987

Stability:

Hygroscopic

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10-34

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

DOTA Usage And Synthesis

Chemical Properties

Colourless crystals

Uses

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.

• It has been used for radiolabeling of carbon nanotube bioconjugates by chelating ⁶⁴Cu radioisotope.
• DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
• It can form complexes with gadolinium for application as MRI contrast agents.
• Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Uses

Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.

Definition

ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.

DOTA(60239-18-1)Related Product Information

• 1,4,7,10-Tetrakis(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane
• DOTA
• Gadoteric acid
• 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2-[(4-isothiocyanatophenyl)methyl]-
• TETRYL
• 12-Crown-4
• Eu-DOTA,Europium DOTA
• TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
• GADOMELITOL
• DOTA-[TYR3]-OCTREOTATE,DOTA-[TYR3]-OCTREOTIDE ACID,DOTA-FCYWKTCT (DISULFIDE BRIDGE: 2-7),DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OH (DISULFIDE BRIDGE: 2-7)
• DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7)
• gadolinium DOTA meglumine
• DOTA-BIM-23014:DOTA-Lanreotide,DOTA-Lanreotide
• DOTA-(Tyr3)-Octreotate
• Iron DOTA Sodium Salt
• DOTA-glycyl-glycyl-glycyl-(4-nitrophenyl)alanine amide
• DOTA-NOC, DOTA-[Nal3]-octreotide,DOTA-NOC
• yttrium-90-DOTA-peptide-chimeric L6