5-Chloro-6-hydroxynicotinic Acid Chemical Properties

Melting point:

≥300 °C(lit.)

Boiling point:

334.6±42.0 °C(Predicted)

Density 

1.4914 (rough estimate)

refractive index 

1.5810 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

3.38±0.50(Predicted)

color 

White to Light yellow to Light orange

CAS DataBase Reference

54127-63-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-37/39-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

2933399990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

5-Chloro-6-hydroxynicotinic Acid Usage And Synthesis

Structure

5-Chloro-6-hydroxynicotinic Acid （5Cl6HNA) was recrystallized four times from ethanol at 345 K. The obtained white crystalline solid was first dried in a vacuum at 1.3 Pa and 353 K. The crystals were then ground with a mortar and a pestle and further dried for 24 h at 1.3 Pa and 353 K. The powder pattern obtained at 295 ± 1 K was indexed as monoclinic, space group P21/c, with a= 5.478 Å, b= 10.545 Å, c= 11.796 Å, β=97.76°. These results are in agreement with those obtained in this work from single crystal X-ray diffraction experiments carried out at 293 ±2K(P21/c, a ) 5.469 Å, b = 10.529 Å, c= 11.795 Å, β= 97.72°). DSC (fusion, β= 2 K ·min-1 ): Ton= 582.2 K and Tmax= 585.6 K[1].

Chemical Properties

white to beige fine crystalline powder

References

[1] Rui C. Santos. “Energetics and Structure of Hydroxynicotinic Acids. Crystal Structures of 2-, 4-, 6-Hydroxynicotinic and 5-Chloro-6-hydroxynicotinic Acids.” The Journal of Physical Chemistry B 113 43 (2009): 14291–14309.

5-Chloro-6-hydroxynicotinic Acid(54127-63-8)Related Product Information

• 2-Hydroxy-5-pyridinecarboxylic acid
• Nicotinic acid
• Ethyl 2-aminopyridine-3-carboxylate
• 3-Nitropyridine
• NICOTINIC-D4 ACID
• Isonicotinic acid
• 2-Aminopyridine N-oxide
• 3,5-DINITROPYRIDINE
• 2-BROMOPYRIDINE N-OXIDE
• 2,5-PYRIDINEDICARBOXYLIC ACID
• 3-Ethylpyridine
• 5-Ethyl-2-methylpyridine
• 2,2'-Bipyridine-5,5'-dicarboxylic acid
• 5-NITRONICOTINIC ACID
• 5-chloro-6-hydroxynicotinonitrile
• 5-Chloro-4,6-dihydroxynicotinic acid ethyl ester
• 5-Choro-6-methoxynicotinic acid
• 5-chloro-2-hydroxy-3-pyridinecarboxylic acid