3-Chloro-2-methylpropene Chemical Properties

Melting point:

-80 °C (lit.)

Boiling point:

71-72 °C (lit.)

Density 

0.925 g/mL at 20 °C (lit.)

vapor density 

3.12 (vs air)

vapor pressure 

102 mm Hg ( 20 °C)

refractive index 

n20/D 1.427(lit.)

Flash point:

9 °F

storage temp. 

2-8°C

solubility 

H2O: insoluble

form 

Liquid

color 

Clear

explosive limit

2.2-10.4%(V)

Water Solubility 

0.5 g/L (20 ºC)

Merck 

14,2148

BRN 

878160

CAS DataBase Reference

563-47-3(CAS DataBase Reference)

IARC

2B (Vol. 63, 115) 2018

NIST Chemistry Reference

1-Propene, 3-chloro-2-methyl-(563-47-3)

EPA Substance Registry System

3-Chloro-2-methyl-1-propene (563-47-3)

Safety Information

Hazard Codes 

F,C,N

Risk Statements 

11-20/22-34-43-51/53

Safety Statements 

9-16-29-36/37/39-45-61-26

RIDADR 

UN 2554 3/PG 2

WGK Germany 

2

RTECS 

UC8050000

Autoignition Temperature

899 °F

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29032900

Hazardous Substances Data

563-47-3(Hazardous Substances Data)

MSDS

• Language:English Provider:3-Chloro-2-methylpropene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Chloro-2-methylpropene Usage And Synthesis

Description

3-Chloro-2-methylpropene is used as an intermediate to produce carbofuran, herbicides, plastics, pharmaceuticals and other organics. It is also used as an additive in textile and perfumes. It was used to study ring opening polymerization of oxirane derivatives using organotin phosphate condensate and cationic polymerization of 3-Chloro-2-methylpropene with AICI3 and AIBr3 as initiators. It is also the reactant for the synthesis of cyclobutanone.

Chemical Properties

clear liquid

Uses

In organic synthesis.

Uses

3-Chloro-2-methylpropene has been used as reactant in the synthesis of cyclobutanone. It is used as an intermediate in the production of plastics, pharmaceuticals and other organic chemicals.

Uses

3-Chloro-2-methyl-1-propene was used to study ring opening polymerization of oxirane derivatives using organotin phosphate condensate. It was used to study cationic polymerization of 3-Chloro-2-methyl-1-propene using using AICI₃ and A₃IBr, as initiators.

Definition

ChEBI: 3-Chloro-2-methylpropene is an organochlorine compound.

Biological Functions

MAC is a valuable index for clinical anesthesia, but it is seldom employed without taking other factors into consideration. For example, inhibiting movement in only 50% of patients is not acceptable. Consequently, if an inhalational agent were being used alone—that is, without the administration of other anesthetics or analgesic drugs—the anesthesiologist would employ a multiple of its MAC value to ensure immobility.MAC is frequently multiplied by a factor of 1.3 to achieve nearly 100% clinical efficacy. On the other hand, useful clinical results may be achieved with doses of anesthetics below MAC levels. For example, mild analgesia and amnesia often occur with doses of inhalational agents that are near 0.5 MAC. In this state, it may even be possible to communicate with patients intraoperatively, while their recall is limited.

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 824, 1981 DOI: 10.1021/jo00317a041

General Description

A colorless to straw-colored liquid with a sharp penetrating odor. Less dense than water and insoluble in water. Flash point below 0°F. May be toxic by ingestion. Irritating to skin and eyes. Used to make plastics and pharmaceuticals.

Air & Water Reactions

Highly flammable. 3-Chloro-2-methylpropene may react with water at elevated temperatures. . Insoluble in water.

Reactivity Profile

3-Chloro-2-methylpropene is sensitive to light. 3-Chloro-2-methylpropene can react vigorously with oxidizers. 3-Chloro-2-methylpropene is incompatible with strong bases. 3-Chloro-2-methylpropene may react with water at elevated temperatures. .

Hazard

Irritant; poison; anesthetic; questionable carcinogen; toxic.

Health Hazard

Inhalation causes irritation of nose and throat. Contact of vapor or liquid with eyes causes irritation. Liquid irritates skin. Ingestion causes irritation of mouth and stomach.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Experimental reproductive effects. An irritant. Human mutation data reported. Very dangerous fire hazard when exposed to heat, flame, or oxidizers. Moderately explosive when exposed to heat or flame. Can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and ALLYL COMPOUNDS.

Carcinogenicity

3-Chloro-2-methylpropene is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

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