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3,5-Dichloroaniline

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3,5-Dichloroaniline Basic information

Product Name:
3,5-Dichloroaniline
Synonyms:
  • 3,5-DCA
  • 3,5-dichloro
  • 3,5-dichloro-anilin
  • 3,5-dichloro-benzenamin
  • Aniline, 3,5-dichloro-
  • Benzenamine,3,5-dichloro-
  • BF352-31
  • m-Dichloroaniline
CAS:
626-43-7
MF:
C6H5Cl2N
MW:
162.02
EINECS:
210-948-9
Product Categories:
  • Anilines, Aromatic Amines and Nitro Compounds
  • Amines
  • C2 to C6
  • Nitrogen Compounds
  • Alpha sort
  • AromaticsPesticides&Metabolites
  • Chemical Class
  • D
  • DAlphabetic
  • DIA - DIC
Mol File:
626-43-7.mol
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3,5-Dichloroaniline Chemical Properties

Melting point:
46-52 °C (lit.)
Boiling point:
259-260 °C/741 mmHg (lit.)
Density 
1.58
refractive index 
1.6000 (estimate)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
0.78g/l
pka
pK1:2.37(+1) (25°C)
form 
crystalline
color 
dark gray
Water Solubility 
0.6 g/L (26 ºC)
BRN 
636492
LogP
2.9 at 20-25℃
CAS DataBase Reference
626-43-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzenamine, 3,5-dichloro-(626-43-7)
EPA Substance Registry System
3,5-Dichloroaniline (626-43-7)
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Safety Information

Hazard Codes 
T,N,Xi
Risk Statements 
23/24/25-33-50/53
Safety Statements 
28-36/37-45-60-61-28A
RIDADR 
UN 3442 6.1/PG 2
WGK Germany 
3
8
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29214210
Hazardous Substances Data
626-43-7(Hazardous Substances Data)

MSDS

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3,5-Dichloroaniline Usage And Synthesis

Chemical Properties

white to brown crystals or needle crystal, soluble in ethanol, ether, diethyl carbonate, insoluble in water, high toxicity, corrosive.

Uses

Dichlorobenzenamine is used in the synthesis of effective inhibitors of plant δ1-pyrroline-4-carboxylate reductase. Also used in the preparation of anti-tumor agents based upon diaryl urea derivatives.

Application

3,5-Dichloroaniline is used in the production of pesticides, dyes and pharmaceuticals. 3,5-Dichloroaniline is an intermediate in the production of fungicides fumonisin, isoxaflutole, vinblastine and myclobutanil.

Preparation

synthesis of 3,5-Dichloroaniline: Add 25% hydrochloric acid and o-nitroaniline in the reaction kettle, turn on the stirring, pass chlorine gas for chlorination at 10-20℃ and negative pressure, after passing chlorine gas, continue to stir for 15min, then filter, and wash the filter cake with water to neutral, that is, 2,4-dichloro-6-nitroaniline.
In another reaction kettle add industrial ethanol, under stirring, then add 2,4-dichloro-6-nitroaniline, add 95% H2SO4 below 40°C, cool to 15°C, add sodium nitrite in batches, after adding sodium nitrite, continue to hold the reaction at 15°C for 4h, then put the material into denitration kettle, slowly heat to reflux temperature 80°C and keep reflux for 2h, then raise the temperature to evaporate ethanol, and then distill the ethanol. Liquid material into the distillation kettle for water distillation, distillation of the resulting oil and water material for stratification, to obtain 3,5-dichloronitrobenzene.
Put a certain amount of water and 3,5-dichloronitrobenzene in the reaction kettle, raise the temperature to reflux under stirring, add a certain concentration of sodium disulfide solution drop by drop in 1h, and keep reflux for 3h, rest stratification, the lower layer of oily material washed with hot water to obtain 3,5-dichloroaniline.

Definition

ChEBI: 3,5-dichloroaniline is a dichloroaniline.

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