3-ETHYL-3-METHYLGLUTARIMIDE Chemical Properties

Melting point:

126-127 °C(lit.)

Boiling point:

279°C (rough estimate)

Density 

1.1174 (rough estimate)

refractive index 

1.4860 (estimate)

storage temp. 

Sealed in dry,2-8°C

Water Solubility 

Soluble in water

solubility 

DMSO:31.0(Max Conc. mg/mL);199.76(Max Conc. mM)
Ethanol:31.0(Max Conc. mg/mL);199.76(Max Conc. mM)

form 

powder

pka

pKa 11.7 (Uncertain)

color 

white

Merck 

14,1027

CAS DataBase Reference

64-65-3(CAS DataBase Reference)

EPA Substance Registry System

Bemegride (64-65-3)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25

Safety Statements 

22-36/37/39-45

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

MA4550000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

2933399990

Toxicity

LD50 in male mice (mg/kg): 20.1 ±1.41 i.v., 43.0 ±1.8 s.c.; LD50 in male rats (mg/kg): 16.3 ±1.24 i.v., 23.5 ±1.67 i.p (Hahn, Oberdorf)

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

3-ETHYL-3-METHYLGLUTARIMIDE Usage And Synthesis

Chemical Properties

white to off-white flakes or powder

Uses

CNS stimulant;GABA antagonist

Definition

ChEBI: 4-ethyl-4-methylpiperidine-2,6-dione is a member of piperidones.

brand name

Megimide (Abbott).

General Description

White crystalline solid. Sublimes at 212°F and 200 mm pressure.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

3-ETHYL-3-METHYLGLUTARIMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition it emits toxic fumes.

Fire Hazard

Flash point data for 3-ETHYL-3-METHYLGLUTARIMIDE are not available. 3-ETHYL-3-METHYLGLUTARIMIDE is probably not flammable.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, intramuscular, subcutaneous, and parented routes. Human systemic effects by ingestion: wakefulness, hallucinations, distorted perceptions, toxic psychosis. An analeptic, central nervous system stimulant; used to counteract barbiturate poisoning. When heated to decomposition it emits toxic fumes of NOx.

3-ETHYL-3-METHYLGLUTARIMIDE(64-65-3)Related Product Information

• BMY 7378 DIHYDROCHLORIDE
• 3,3-Pentamethylene glutarimide
• 3,3-Tetramethyleneglutarimide
• Buspirone
• Tiospirone
• Binospirone
• Buspirone hydrochloride
• 3-ETHYL-3-METHYLGLUTARIMIDE
• Glutarimide
• 2,4-dioxo-3-azaspiro[5.5]undecane-1,5-dicarbonitrile
• ALNESPIRONE
• 8-[2-(1,4-BENZODIOXAN-2-YLMETHYLAMINO)ETHYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE HYDROCHLORIDE
• BUSPIRONE (D8)
• ALPHA,ALPHA'-DICYANO-B-ETHYL-B-METHYLGLUTARIMIDE,2,4-DICYANO-3-ETHYL-3-METHYLGLUTARIMIDE,ALPHA,ALPHA'-DICYANO-BETA-ETHYL-BETA-METHYLGLUTARIMIDE
• 3-methylglutarimide
• 8-[3-(1H-IMIDAZOL-1-YL)PROPYL]-8-AZASPIRO[4.5]DECANE-7,9-DIONE
• 8-(4-((3,4-Dihydro-2H-1-benzothiopyran-8-yl)oxy)butyl)-8-azaspiro(4.5) decane-7,9-dione
• (S)-(-)-AMINOGLUTETHIMIDE