Basic information Safety Supplier Related

CARDAMONIN

Basic information Safety Supplier Related

CARDAMONIN Basic information

Product Name:
CARDAMONIN
Synonyms:
  • (E)-1-(2,4-DIHYDROXY-6-METHOXY-PHENYL)-3-PHENYL-PROPENONE
  • (E)-1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-phenyl-
  • 1-(2,4-Dihydroxy-6-methoxyphenyl)
  • -3-phenylprop-2-en-1-one
  • 1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-phenylprop-2-en-1-one
  • Cardamoni
  • 2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-
  • Natural Alpinia Seed Extract 98% Cardamonin Powder CAS?18956-16-6
CAS:
18956-16-6
MF:
C16H14O4
MW:
270.28
Mol File:
18956-16-6.mol
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CARDAMONIN Chemical Properties

Melting point:
178 °C
Boiling point:
484.5±45.0 °C(Predicted)
Density 
1.282±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 125 mg/mL (462.48 mM)
form 
Solid
pka
7.00±0.40(Predicted)
color 
Light yellow to yellow
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CARDAMONIN Usage And Synthesis

Uses

1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one is inhibits NO and PGE2 production and inhibits TXB2 production.

Definition

ChEBI: Cardamonin is a member of chalcones.

in vivo

Cardamonin (oral gavage; 20, 40 or 80 mg/kg; once) treatments alleviates doxorubicin-induced cardiotoxicity and inhibits apoptosis in doxorubicin-challenged mice[4].

Animal Model:Male C57BL/6 J mice (8 weeks old, 20-22 g)[4]
Dosage:20, 40 or 80 mg/kg
Administration:Oral gavage; 20, 40 or 80 mg/kg; once
Result:Rescued the reduction of LVEF% and LVFS% by doxorubicin, reduced the increasement of serum LDH, CK-MB and Tn-T levels by doxorubicin in a dose-dependent manner, improved doxorubicin-induced histological changes, and attenuated collagen accumulation in cardiac sections by doxorubicin in a dose-dependent manner.
Animal Model:Male C57BL/6 J mice (8 weeks old, 20-22 g)[4]
Dosage:20, 40 or 80 mg/kg
Administration:Oral gavage; 20, 40 or 80 mg/kg; once
Result:Rescued Bcl-2, and inhibited Bax and Caspase-3 cleavage in heart tissues from doxorubicin-challenged mice.

CARDAMONINSupplier

Beijing HwrkChemical Technology Co., Ltd
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18515581800 18501085097
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sales.bj@hwrkchemical.com
BeiJing Hwrk Chemicals Limted
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0757-86329057 18934348241
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sales4.gd@hwrkchemical.com
Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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sales@chemwish.com
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54098501
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sales@sinch.com.cn
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Email
product02@bidepharm.com
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CARDAMONIN(18956-16-6)Related Product Information