Transglutaminase
Transglutaminase Basic information
- Product Name:
- Transglutaminase
- Synonyms:
-
- EC 2.3.2.13
- FACTOR XIII-A, HUMAN
- PROTEIN-GLUTAMINE: AMINE GAMMA-GLUTAMYLTRANSFERASE
- akuthibatg
- akuthibatg-k
- glutaminylpeptidegamma-glutamyltransferas
- glutaminylpeptidegammaglutamyltransferase
- Glutamine transaminase
- CAS:
- 80146-85-6
- MF:
- C27H44O3H2O
- MW:
- 0
- EINECS:
- 232-554-6
- Mol File:
- Mol File
Transglutaminase Chemical Properties
- storage temp.
- -20°C
- solubility
- H2O: soluble1.0mg/mL, clear
- form
- lyophilized powder
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-26
- WGK Germany
- 1
- RTECS
- MA2370000
- F
- 10
MSDS
- Language:English Provider:SigmaAldrich
Transglutaminase Usage And Synthesis
Uses
transglutaminase is an enzyme said to activate the skin’s physiological functions.
Uses
Transglutaminase has been used in a study to improve quantifiable assays to fully characterize the role of transglutaminase in diseases such as Huntington′s disease and Alzheimer′s disease.Transglutaminase has also been used in a study to develop a nonradioactive dot blot assay for transglutaminase activity.
Biochem/physiol Actions
Transglutaminase from guinea pig liver consists of a single polypeptide chain of 691 amino acid residues. It has six potential glycosylation sites (Asn-X-Ser or Asn-X-Thr), but it is not glycosylated. The molecular mass is approximately 76.6 kDa. It is calcium dependent and has several calcium binding sites. The enzyme is inhibited by iodoacetamide and N-ethylmaleimide in the presence of calcium. It catalyzes the incorporation of small molecular weight amines into γ-glutamine sites of proteins. In the absence of small molecular weight amines, it catalyzes the cross linking of proteins that results in the formation of γ-glutamyl-ε-lysine side chain peptides. Liver transglutaminase is a nonzymogenic enzyme.
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Transglutaminase(80146-85-6)Related Product Information
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- COBALT(II) ACETYLACETONATE
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- Benzyl isocyanide
- 2,4-PENTANEDIONE, SILVER DERIVATIVE
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- METHYL ISOCYANOACETATE
- N-BUTYLISOCYANIDE
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- DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
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