3-(4-FLUOROBENZOYL)PROPIONIC ACID Chemical Properties

Melting point:

100-102 °C (lit.)

Boiling point:

374.4±22.0 °C(Predicted)

Density 

1.2441 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

powder to crystal

pka

4.50±0.17(Predicted)

color 

White to Orange to Green

Water Solubility 

Insoluble in water.

BRN 

958145

CAS DataBase Reference

366-77-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,C,Xi

Risk Statements 

36/37/38-20/21/22-22

Safety Statements 

36/37/39-26-22-24/25

WGK Germany 

3

Hazard Note 

Corrosive

HazardClass 

IRRITANT

HS Code 

29183000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-(4-FLUOROBENZOYL)PROPIONIC ACID Usage And Synthesis

Chemical Properties

beige granular powder

Uses

7-Fluoro-1-tetralone was prepared from 3-(4-fluorobenzoyl)-propionic acid by Wolff-Kishner reduction followed by ring closure with polyphosphoric acid and other substituted 1-tetralones where commercially available. Reduction of 3-(4-fluorobenzoyl)propionic acid with an excess of tert-butylamine borane (TBAB) in the presence of AlCl3 provided 4-(4-fluorophenyl)-1-butanol (87) in 63% yield for the synthesis of LM-1507 sodium salt. Penfluridol 1-[4,4-bis(4-fluorophenyl)butyl]-4-(4-chloro-3-trifluoromethylphenyl)- 4-hydroxypiperidine, C 28 H 27 ClF 5 NO, M r 523.99, mp 105 - 107°C, is obtained by reducing the ketone of 3-(4-fluorobenzoyl)propionic acid into a lactone.

Definition

ChEBI: 4-(4-Fluorophenyl)-4-oxobutanoic acid is an aromatic ketone.

General Description

3-(4-Fluorobenzoyl)propionic acid is a metabolite of haloperidol, a dopamine D2 receptor blocker.

3-(4-FLUOROBENZOYL)PROPIONIC ACID(366-77-8)Related Product Information

• 3-(2',4'-DIFLUOROBENZOYL)PROPIONIC ACID
• METHYL 4-(4-FLUOROPHENYL)-2,4-DIOXOBUTANOATE
• 3-(4-FLUOROBENZOYL)PROPIONIC ACID
• Haloperidol
• ethyl 4-(2,4-difluorophenyl)-2,4-dioxobutanoate
• TRANS-2-(4-FLUOROBENZOYL)CYCLOPENTANE-1-CARBOXYLIC ACID
• 2-METHYL-4-OXO-4-(4'-FLUOROPHENYL)BUTYRIC ACID
• 4-(3,4-DIFLUOROPHENYL)-4-OXOBUTYRIC ACID
• TRANS-2-(4-FLUOROBENZOYL)-1-CYCLOHEXANE-CARBOXYLIC ACID, 99
• CIS-2-(4-FLUOROBENZOYL)-1-CYCLOHEXANE-CARBOXYLIC ACID, 99
• ETHYL 4-(3,4-DIFLUOROPHENYL)-2,2-DIMETHYL-4-OXOBUTYRATE
• ETHYL 4-(4-FLUOROPHENYL)-4-OXOBUTYRATE
• CIS-2-(4-FLUOROBENZOYL)CYCLOPENTANE-1-CARBOXYLIC ACID
• ETHYL 4-(3,4-DIFLUOROPHENYL)-4-OXOBUTYRATE
• 4-OXO-4-(3,4,5-TRIFLUOROPHENYL)BUTYRIC ACID
• ETHYL 4-(2,4-DIFLUOROPHENYL)-4-OXOBUTYRATE
• ETHYL 4-OXO-4-(3,4,5-TRIFLUOROPHENYL)BUTYRATE
• 4-(4-fluorophenyl)-4-oxo-2-[(2-thienylmethyl)amino]butanoic acid