D-2-Phenylglycine Chemical Properties

Melting point:

302 °C (dec.)(lit.)

alpha 

-156 º (c=1,1N HCl)

Boiling point:

273.17°C (rough estimate)

Density 

1.2 g/cm3 (20℃)

vapor pressure 

0Pa at 25℃

refractive index 

-158 ° (C=1, 1mol/L HCl)

Flash point:

150 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Aqueous Acid (Sparingly), Water (Slightly, Heated)

pka

1.94±0.10(Predicted)

form 

Crystalline Powder

color 

White

optical activity

[α]20/D 155°, c = 1 in 1 M HCl

Water Solubility 

0.3g/100mL

Merck 

14,7291

BRN 

2208676

LogP

-1.76 at 20℃

CAS DataBase Reference

875-74-1(CAS DataBase Reference)

NIST Chemistry Reference

d a-Phenylglycine(875-74-1)

EPA Substance Registry System

Benzeneacetic acid, .alpha.-amino-, (.alpha.R)- (875-74-1)

Safety Information

Hazard Codes 

T

Risk Statements 

23/24/25-36/37/38-22-20

Safety Statements 

22-24/25-45-36/37/39-26-44-28-7-4

WGK Germany 

3

TSCA 

Yes

HS Code 

29224995

MSDS

• Language:English Provider:D(-)-alpha-Phenylglycine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

D-2-Phenylglycine Usage And Synthesis

Description

L-phenylglycine (Cephalexin EP Impurity A) is a derivative of glycine, a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in the spinal cord and an allosteric modulator of NMDA receptors.

Storage

Store at room temperature. Store in cool dry place in tightly closed container. Store away from oxidizing agent.

Description

d-Phenylglycine is widely used in large quantity as the side chain that makes ampicillin and cephalexin orally acceptable.

Chemical Properties

White crystalline powder

Uses

D-(-)-2-Phenylglycine (Cefalexin EP Impurity A) is the derivative of glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Uses

D-(-)-2-Phenylglycine is the derivative of glycine (G615990), a non-essential amino acid for human development. Glycine is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA r eceptors.

Definition

ChEBI: The R stereoisomer of alpha-phenylglycine.

Flammability and Explosibility

Non flammable

Synthesis

Industrially, dphenylglycine has been produced by a conventional resolution method or by kinetic resolution with acylase. Another enzymatic procedure has been developed by Yamada et al. , as shown below.

D-2-Phenylglycine(875-74-1)Related Product Information

• (S)-Amlodipine
• Diethylstilbestrol
• 4-Aminophenylacetic acid
• Citric acid
• Anilinoacetic acid
• α-Lipoic Acid
• Folic acid
• Glycine
• Ethyl 2-(Chlorosulfonyl)acetate
• 4-Hydroxy-D-(-)-2-phenylglycine
• Potassium (R)-[(3-ethoxy-1-methyl-3-oxoprop-1-enyl)amino]phenylacetate
• D(-)-Phenylglycinamide
• Methyl D-(-)-4-hydroxy-phenylglycinate
• Ascoric Acid
• 3-Hydroxy-4-Methyl-2(5H)-thiophenone
• (6R-trans)-7-[(2,2-diMethyl-1-oxopropyl)aMino]-3-Methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
• 7-Amino-3-methyl-3-cephem-4-carboxylic acid
• 7-Amino-3-chloro cephalosporanic acid