Basic information Safety Supplier Related

OLEYLHYDROXAMIC ACID

Basic information Safety Supplier Related

OLEYLHYDROXAMIC ACID Basic information

Product Name:
OLEYLHYDROXAMIC ACID
Synonyms:
  • OLEYLHYDROXAMIC ACID
  • N-hydroxyoleamide
  • (9Z)-9-Octadecenehydroxamic acid
  • (Z)-N-Hydroxy-9-octadecenamide
  • Hydroxamate derivative of oleic acid
  • N-Hydroxyoleic amide
  • Oleoylhydroxamic acid
  • 9-Octadecenamide, N-hydroxy-, (9Z)-
CAS:
10335-69-0
MF:
C18H35NO2
MW:
297.48
EINECS:
2337284
Mol File:
10335-69-0.mol
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OLEYLHYDROXAMIC ACID Chemical Properties

Melting point:
61 °C
Density 
0.921±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤50mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
form 
crystalline solid
pka
9.48±0.20(Predicted)
color 
White to off-white
EPA Substance Registry System
N-Hydroxyoleylamide (10335-69-0)
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OLEYLHYDROXAMIC ACID Usage And Synthesis

Biological Activity

mmp-2 inhibitor i, a hydroxamate-based, long-chain fatty acid, is a reversible inhibitor of matrix metalloproteinase (mmp)-2.matrix metalloproteinases (mmps) have been involved in the degradation of extracellular matrix. mmps contribute to long-term remodeling processes such as embryogenesis, tumor invasion, inflammation, angiogenesis, and wound healing. mmp-2, also known as gelatinase a or type iv collagenase, has been involved in regulating diverse cellular functions independent of its action on the extracellular matrix, including vascular tone, platelet aggregation, and mediation of the acute mechanical dysfunction of the heart immediately after ischemia and reperfusion [2]. up-regulation of mmp-2 has been associated with tumor invasion and metastasis [3].mmp-2 inhibitor i inhibited the activity of matrix metalloproteinase (mmp)-2 with the ki value of 1.6 μm [1]. mmp-2 inhibitor i attenuated cancer cell migration [3]. mmp-2 inhibitor i had also been used to preserve blood-brain barrier function in a wistar rat model of pneumococcal meningitis [4].

References

[1] berton a, rigot v, huet e, et al. involvement of fibronectin type ii repeats in the efficient inhibition of gelatinases a and b by long-chain unsaturated fatty acids[j]. journal of biological chemistry, 2001, 276(23): 20458-20465.
[2] wang w, schulze c j, suarez-pinzon w l, et al. intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury[j]. circulation, 2002, 106(12): 1543-1549.
[3] emmert-buck m r, roth m j, zhuang z, et al. increased gelatinase a (mmp-2) and cathepsin b activity in invasive tumor regions of human colon cancer samples[j]. the american journal of pathology, 1994, 145(6): 1285.
[4] barichello t, generoso j s, michelon c m, et al. inhibition of matrix metalloproteinases-2 and-9 prevents cognitive impairment induced by pneumococcal meningitis in wistar rats[j]. experimental biology and medicine, 2014, 239(2): 225-231.

OLEYLHYDROXAMIC ACIDSupplier

ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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Tianmen Hengchang Chemical Co., Ltd
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Hubei Qifei Pharmaceutical Chemical Co., Ltd
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027-027-59322506 18071128681
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Shaanxi Dideu Newmaterial Co., Ltd.
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029-87576359 15353716720
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