5,7-DIBROMO-8-HYDROXYQUINOLINE Chemical Properties

Melting point:

198-200 °C(lit.)

Boiling point:

363.74°C (rough estimate)

Density 

2.189

refractive index 

1.6400 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)

form 

Solid

pka

2.23±0.30(Predicted)

color 

Off-White to Pale Beige

Merck 

14,1453

BRN 

153624

CAS DataBase Reference

521-74-4(CAS DataBase Reference)

EPA Substance Registry System

Broxyquinoline (521-74-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

2

RTECS 

VC5300000

F 

8

TSCA 

Yes

HS Code 

29334900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

5,7-DIBROMO-8-HYDROXYQUINOLINE Usage And Synthesis

Chemical Properties

almost white powder

Originator

Brodiar,Intervet

Uses

antiinfectant, disinfectant

Uses

In testing for Cu, Fe, Ti.

Uses

5,7-Dibromoquinolin-8-ol

Definition

ChEBI: 5,7-dibromo-8-quinolinol is a member of quinolines and an organohalogen compound.

Manufacturing Process

To a suspension of 14.5 g of 8-hydroxyquinoline in 400 ml of water was added dropwise a solution of 32.3 g bromine and 30 g 8% aqueous hydrobromide in 30 ml water. A temperature of reaction mixture decreased to 33°C. Stirring was continued for 30 min, a fine yellow 5,7-dibromo-8-hydroxyquinoline was collected by filtration, washed with water and dried; yield 29.8 g (98.4%), melting point 201°C.

brand name

Aprilin;Auanosept;Dibromoksin;Dibromoquin;Dibromoxine;Digesept;Diromo;Dirorno;Dysentrocym;Enosept;Enterokvin;Intestopan-q;Noroquinol;Paramibrodiar;Phenipan;Sandocycline;Sandoin;Starogyn;Susiform ad is vet.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Broxyquinoline is a halogenated hydroxyquinoline. See entry for halogenated hydroxyquinoline derivatives and WHO comment for clioquinol.

Purification Methods

Crystallise it from acetone/EtOH. It can be sublimed. [Beilstein 21/3 V 290.]

5,7-DIBROMO-8-HYDROXYQUINOLINE(521-74-4)Related Product Information

• Quinhydrone
• 6-Hydroxyquinoline
• Dibromomethane
• 7-Hydroxyquinoline
• Thioacetamide
• ACETONE-D6
• 8-Hydroxyquinoline
• broxaldine
• 5,7-DIBROMO-8-HYDROXYQUINOLINE
• broquinaldol
• 6,8-DIBROMO-2-HYDROXYQUINOLINE
• 3,6-DIBROMO-4-HYDROXYQUINOLINE
• 5,7-DIBROMO-8-HYDROXYQUINOLINE, (5,7-DIBROMO-8-QUINOLINOL)
• Dibromo-8-Hydroxyquinoline
• [(5,7-dibromoquinolin-8-yl)oxy]acetic acid
• 2-[(5,7-dibromoquinolin-8-yl)oxy]propanoic acid
• 3-[(5,7-dibromoquinolin-8-yl)oxy]propanoic acid
• (2R,3R,4S,5R)-2-(ACETOXYMETHYL)-6-(5,7-DIBROMOQUINOLIN-8-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4,5-TRIYL TRIACETATE