L-ETHIONINE Chemical Properties

Melting point:

280 °C (dec.)(lit.)

alpha 

D24 +25.1°; D23 +20.1° (1N HCl) (Armstrong, Lewis)

Density 

1.085 (estimate)

refractive index 

22 ° (C=1, 1mol/L HCl)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Aqueous Acid (Slightly), Water (Slightly)

form 

solid

Boiling point:

310.4±37.0 °C(Predicted)

pka

2.23±0.10(Predicted)

color 

White to Off-White

Merck 

14,3738

CAS DataBase Reference

13073-35-3(CAS DataBase Reference)

EPA Substance Registry System

L-Ethionine (13073-35-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

WGK Germany 

3

RTECS 

ES6825300

HS Code 

2930.90.4950

Hazardous Substances Data

13073-35-3(Hazardous Substances Data)

Toxicity

rat,LD,intraperitoneal,> 1gm/kg (1000mg/kg),LIVER: OTHER CHANGESLIVER: CHANGES IN LIVER WEIGHT,Acta Pathologica Japonica. Vol. 39, Pg. 281, 1989.

MSDS

• Language:English Provider:SigmaAldrich

L-ETHIONINE Usage And Synthesis

Chemical Properties

White Solid

Uses

Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver.

Definition

ChEBI: An S-ethylhomocysteine that has S-configuration at the chiral centre.

Purification Methods

Likely impurities are N-acetyl-(R and S)-ethionine, S-methionine, and R-ethionine. Crystallise it from water by adding 4volumes of EtOH or 85% aqueous EtOH. It sublimes at 196-216o/0.3mm with 99.1% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Weiss & Stekol J Am Chem Soc 73 2399 1951, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2658, 2659 1961, Beilstein 4 IV 3194.]

L-ETHIONINE(13073-35-3)Related Product Information

• S-ADENOSYL-L-METHIONINE IODIDE SALT
• 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE
• L-ETHIONINE
• S-Adenosyl-L-methionine tosylate
• L-CYSTATHIONINE
• S-ADENOSYL-L-METHIONINE
• Ademetionine disulfate tosylate
• Spirapril
• FMOC-HOMOCYS(TRT)-OH
• L-BUTHIONINE-(S,R)-SULFOXIMINE
• Ethionine ester
• DL-Ethionine,98%,(.+/-.)-Ethionine,(+-)-ethionin
• D-ETHIONINE,D(-)-ETHIONINE,D-ETHIONINE 98%
• S-Adenosyl-L-methionine
• N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ETHIONINE,FMOC-L-ETHIONINE
• N-ALPHA-T-BUTOXYCARBONYL-L-ETHIONINE,BOC-L-ETHIONINE
• S-ADENOSYL-L-METHIONINE, [METHYL-14C]
• (2S,4R)-FMOC-4-TRITYLMERCAPTO-PYRROLIDINE-2-CARBOXYLIC ACID