L-ETHIONINE
L-ETHIONINE Basic information
- Product Name:
- L-ETHIONINE
- Synonyms:
-
- s-ethyl-homocystein
- s-ethyl-l-homocystein
- L-ETHIONINE
- L-2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID
- H-ETH-OH
- S-ethyl-L-homocysteine
- L -ETHIONINE 99%
- L-ETHIONINE 98+%
- CAS:
- 13073-35-3
- MF:
- C6H13NO2S
- MW:
- 163.24
- EINECS:
- 235-966-4
- Product Categories:
-
- Amino acids methyl、ethyl、t-butyl series
- Amino Acids & Derivatives
- Amino Acids
- Amino Acids 13C, 2H, 15N
- Sulfur & Selenium Compounds
- Mol File:
- 13073-35-3.mol
L-ETHIONINE Chemical Properties
- Melting point:
- 280 °C (dec.)(lit.)
- alpha
- D24 +25.1°; D23 +20.1° (1N HCl) (Armstrong, Lewis)
- Density
- 1.085 (estimate)
- refractive index
- 22 ° (C=1, 1mol/L HCl)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Aqueous Acid (Slightly), Water (Slightly)
- form
- solid
- Boiling point:
- 310.4±37.0 °C(Predicted)
- pka
- 2.23±0.10(Predicted)
- color
- White to Off-White
- Merck
- 14,3738
- CAS DataBase Reference
- 13073-35-3(CAS DataBase Reference)
- EPA Substance Registry System
- L-Ethionine (13073-35-3)
Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- RTECS
- ES6825300
- HS Code
- 2930.90.4950
- Hazardous Substances Data
- 13073-35-3(Hazardous Substances Data)
- Toxicity
- rat,LD,intraperitoneal,> 1gm/kg (1000mg/kg),LIVER: OTHER CHANGESLIVER: CHANGES IN LIVER WEIGHT,Acta Pathologica Japonica. Vol. 39, Pg. 281, 1989.
MSDS
- Language:English Provider:SigmaAldrich
L-ETHIONINE Usage And Synthesis
Chemical Properties
White Solid
Uses
Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver.
Definition
ChEBI: An S-ethylhomocysteine that has S-configuration at the chiral centre.
Biological Activity
An analog of methionine th at interferes with the normal methylation of DNA and other methylation pathways, and induces pancreatic toxicity and liver cancer. However, in animal studies, it has also been shown to act synergistically with methionine-depletion to block the growth and metastasis of methionine-dependent tumors.
Purification Methods
Likely impurities are N-acetyl-(R and S)-ethionine, S-methionine, and R-ethionine. Crystallise it from water by adding 4volumes of EtOH or 85% aqueous EtOH. It sublimes at 196-216o/0.3mm with 99.1% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Weiss & Stekol J Am Chem Soc 73 2399 1951, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2658, 2659 1961, Beilstein 4 IV 3194.]
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L-ETHIONINE(13073-35-3)Related Product Information
- S-ADENOSYL-L-METHIONINE IODIDE SALT
- 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE
- L-ETHIONINE
- S-Adenosyl-L-methionine tosylate
- L-CYSTATHIONINE
- S-ADENOSYL-L-METHIONINE
- Ademetionine disulfate tosylate
- Spirapril
- FMOC-HOMOCYS(TRT)-OH
- L-BUTHIONINE-(S,R)-SULFOXIMINE
- Ethionine ester
- DL-Ethionine,98%,(.+/-.)-Ethionine,(+-)-ethionin
- D-ETHIONINE,D(-)-ETHIONINE,D-ETHIONINE 98%
- S-Adenosyl-L-methionine
- N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ETHIONINE,FMOC-L-ETHIONINE
- N-ALPHA-T-BUTOXYCARBONYL-L-ETHIONINE,BOC-L-ETHIONINE
- S-ADENOSYL-L-METHIONINE, [METHYL-14C]
- (2S,4R)-FMOC-4-TRITYLMERCAPTO-PYRROLIDINE-2-CARBOXYLIC ACID