DL-NORPHENYLEPHRINE HYDROCHLORIDE
DL-NORPHENYLEPHRINE HYDROCHLORIDE Basic information
- Product Name:
- DL-NORPHENYLEPHRINE HYDROCHLORIDE
- Synonyms:
-
- alpha-(aminomethyl)-3-hydroxy-benzenemethanohydrochloride
- alpha-aminomethyl-3-hydroxy-benzylalcohohydrochloride
- m-octopaminehydrochloride
- norfenefrin
- Phenylephrine Hydrochloride Impurity A
- α-(AMinoMethyl)-3-hydroxybenzeneMethanol
- 3-(2-aMino-1-hydroxyethyl)phenol hydrochloride
- Phenylephrine Impurity A HCl (racemic Norphenylephrine HCl)
- CAS:
- 4779-94-6
- MF:
- C8H12ClNO2
- MW:
- 189.64
- EINECS:
- 225-323-6
- Product Categories:
-
- Impuritues
- Amines
- API
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 4779-94-6.mol
DL-NORPHENYLEPHRINE HYDROCHLORIDE Chemical Properties
- Melting point:
- 162-164 °C(lit.)
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Merck
- 14,6699
MSDS
- Language:English Provider:SigmaAldrich
DL-NORPHENYLEPHRINE HYDROCHLORIDE Usage And Synthesis
Chemical Properties
white to almost white crystalline powder
Originator
Zordel,Grelan,Japan,1970
Uses
rac Norphenylephrine Hydrochloride is an Impurity A of phenylephrine. A phenylephrine derivative as leukotriene D4 antagonists.
Definition
ChEBI: Norfenefrine hydrochloride is a member of phenols.
Manufacturing Process
100 parts of the hydrochloride of meta-hydroxy-ω-aminoacetophenone of melting point 220°C to 222°C (obtainable by brominating metaacetoxyacetophenone, causing the bromoketone to react with sodium iodide, adding hexamethylenetetramine to the iodide in an indifferent solvent and scission of the addition product in acid solution) are shaken in aqueous solution with hydrogen in presence of 2 parts of palladium catalyst until 2 atomic proportions of hydrogen have been absorbed. The catalyst is now filtered and the filtrate evaporated in a vacuum; and the crystalline and completely dry residue is dissolved in absolute alcohol and a precipitate is produced by adding dry ether. The hydrochloride of metahydroxyphenylethanolamine thus obtained forms white crystals of melting point 159°C to 160°C.
Therapeutic Function
Adrenergic
DL-NORPHENYLEPHRINE HYDROCHLORIDESupplier
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DL-NORPHENYLEPHRINE HYDROCHLORIDE(4779-94-6)Related Product Information
- Phenylephrine hydrochloride
- 1,2,3,4-Tetrahydro-4,8-dihydroxy-2-methyl-isoquinoline
- Phenylephrine EP Impurity D
- Phenylephrine EP Impurity D
- 3-Hydroxy-4-[[(2R)-2-hydroxy-2-(3-hydroxyphenyl)ethyl]MethylaMino]-4-oxo-butanoic Acid
- 1,2,3,4-Tetrahydro-4,6-dihydroxy-2-methyl-isoquinoline
- N-ACETYL-4-BENZOQUINONE IMINE
- Phenylephrine Impurity 32
- N-(2-Succinyl) Phenylephrine
- 2,2-Dichloro-1-(3-hydroxyphenyl)-ethanone
- benzyl(3-hydroxyphenacyl)methylammonium chloride
- N-Acetylphenylephrine
- DL-NORPHENYLEPHRINE HYDROCHLORIDE
- 1-(3-Hydroxyphenyl)-2-(methylamino)ethanone hydrochloride
- (R)-(-)-Phenylephrine-d3 HCl
- 2-AMINO-3'-HYDROXY-ACETOPHENONE HYDROCHLORIDE
- Phenylephrine Impurity 33
- rac Benzyl Phenylephrine
- Norphenylephrine Hydrochloride