METHYLSULFONYLACETONITRILE Chemical Properties

Melting point:

81-84 °C(lit.)

Boiling point:

360.6±25.0 °C(Predicted)

Density 

1.288±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Powder or Crystalline Powder

color 

White to off-white

Water Solubility 

Slightly soluble in water.

BRN 

969929

CAS DataBase Reference

2274-42-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

20/21/22

Safety Statements 

22-26-36

RIDADR 

UN 3439 6.1/PG 3

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

2926907090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

METHYLSULFONYLACETONITRILE Usage And Synthesis

Uses

Methylsulfonylacetonitrile is used in preparation of substituted pyrimidinylamino isoquinoline and naphthyridine compounds as inhibitors of mutant forms of EGFR.

Uses

(Methylsulfonyl)acetonitrile was used in the synthesis of:

• substituted δ-pyrone ring analogues
• 4,9-dihydropyrrolo[2,1-b]quinazolines containing electron withdrawing groups at the 3-position

Definition

ChEBI: (methylsulfonyl)acetonitrile is an aliphatic nitrile.

METHYLSULFONYLACETONITRILE(2274-42-2)Related Product Information

• 4-CHLOROPHENYLSULFONYLACETONITRILE
• METHYLSULFONYLACETONITRILE
• N-HEXANESULFONYLACETONITRILE
• 2-PYRIDINESULFONYLACETONITRILE
• 4-(Methylphenyl)sulfonylacetonitrile
• THIOPHENE-2-SULFONYLACETONITRILE
• SULPHONYLDIACETONITRILE
• (PHENYLSULFONYL)ACETONITRILE
• Acetonitrile
• 2-(TERT-BUTYLSULFONYL)-3-ETHOXYACRYLONITRILE
• 2-[(4-CHLOROBENZYL)SULFONYL]ACETONITRILE
• 3-ETHOXY-2-(ISOPROPYLSULFONYL)ACRYLONITRILE
• 2-(2-NAPHTHYLSULFONYL)ACETONITRILE
• 3-ETHOXY-2-(2-NAPHTHYLSULFONYL)ACRYLONITRILE
• 2-(TERT-BUTYLSULFONYL)ACETONITRILE
• 3-ETHOXY-2-(PROPYLSULFONYL)ACRYLONITRILE
• 1-PROPANESULPHONYLACETONITRILE
• 2-PROPANESULPHONYLACETONITRILE