Basic information Safety Supplier Related

PHYSALIEN

Basic information Safety Supplier Related

PHYSALIEN Basic information

Product Name:
PHYSALIEN
Synonyms:
  • PHYSALIEN
  • (3R,3R')-beta,beta-carotene-3,3'-diyl dipalmitate
  • PHYSALIEN(ST)
  • PHYSALIEN WITH TLC
  • β,β-Carotene-3β,3'β-diol dipalmitate
  • PHYSALIEN(RG)
  • Zeaxanthin Impurity 1
  • β,β-Carotene-3,3'-diol, 3,3'-dihexadecanoate, (3R,3'R)-
CAS:
144-67-2
MF:
C72H116O4
MW:
1045.69
EINECS:
205-635-9
Product Categories:
  • Carotenoids
Mol File:
144-67-2.mol
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PHYSALIEN Chemical Properties

Melting point:
98～100℃
Boiling point:
956.4±65.0 °C(Predicted)
Density 
0.96±0.1 g/cm3(Predicted)
storage temp. 
Store at -20℃，protected from light
solubility 
Ethanol: slightly soluble
form 
A crystalline solid
color 
Brown to reddish brown
LogP
26.908 (est)
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PHYSALIEN Usage And Synthesis

Uses

Zeaxanthin dipalmitate is an antioxidant carotenoid compound, and is the main carotenoid in Lycium barbarum and Lycium chinense fruits. Zeaxanthin dipalmitate from Lycium chinense has been shown to reduce experimentally induced hepatic fibrosis in rats.

Definition

ChEBI: Physalien is a xanthophyll.

in vivo

Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) reduces the serum ALT and AST levels increased by long-term ethanol challenge in at AFLD Model[1].
Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) effectively attenuates the histological injury[1].
Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) attenuates the AFLD-induced hepatic apoptosis (reveal by caspase-3/7 activity) and inflammation (TNF-α) in rat[1].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the visual behavior of rd10 mice and delays the degeneration of retinal photoreceptors[2].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the light responses of photoreceptors, bipolar cells and retinal ganglion cells[2].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) reduces the expression of genes that are involved in inflammation, apoptosis and oxidative stress in rd10 mice[2].

Purification Methods

Purify it by chromatography on water-deactivated alumina, using hexane/diethyl ether (19:1) to develop the column. It crystallises

PHYSALIENSupplier

Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Anhui kuer Bioengineering Co., Ltd
Tel
0551-65171243 13856024262
Email
kuer@kuerhuaxue.com
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-028-85370565-229-229 18080489829
Email
18080489829@163.com
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