Basic information Safety Supplier Related

MORPHINIUM CHLORIDE

Basic information Safety Supplier Related

MORPHINIUM CHLORIDE Basic information

Product Name:
MORPHINIUM CHLORIDE
Synonyms:
  • 6-alpha-diol,7,8-didehydro-4,5-alpha-epoxy-17-methyl-morphinan-hydrochlo
  • ampek
  • morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-methyl-,hydrochloride,(5-alpha
  • morphinechlorhydrate
  • morphinechloride
  • theba-intran
  • MORPHIN-HCL
  • MORPHINIUM CHLORIDE
CAS:
52-26-6
MF:
C17H20ClNO3
MW:
321.8
EINECS:
200-136-2
Mol File:
52-26-6.mol
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MORPHINIUM CHLORIDE Chemical Properties

Melting point:
about 200° (dec)
alpha 
D25 -113.5° (c = 2.2 in H2O, anhydr basis)
storage temp. 
−20°C
solubility 
Soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in toluene.
form 
Powder
Water Solubility 
Soluble to 50 mM in water
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Safety Information

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-24-33-36/37-45
RIDADR 
UN 1230 3/PG 2
WGK Germany 
1
Toxicity
LD50 in mice (mg/kg): 226-318 i.v. (Buchwald, Eadie)

MSDS

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MORPHINIUM CHLORIDE Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder or colourless, silky needles or cubical masses, efflorescent in a dry atmosphere.

Uses

Opioid receptor agonist; analgesic.

Definition

ChEBI: The hydrochloride salt of morphine.

Contact allergens

Morphine bitartrate caused contact dermatitis in a worker at a plant producing opium alkaloids. Morphine hydrochloride and morphine bitartrate showed patchtest- positive reactions in another patient with contact dermatitis working in the production of concentrated poppy straw. We observed a concomitant reaction between a morphine base and a codeine base in a patient with drug skin eruption due to codeine.

Safety Profile

Poison by ingestion, intraperitoneal, intravenous, parenteral, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Abuse leads to habituation or addiction. When heated to decomposition it emits very toxic fumes of NOx and HCl.

storage

Store at RT

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